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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/2208
Title: Mechanical and biological investigations of chitosan-polyvinyl alcohol based ZrO2 doped porous hybrid composites for bone tissue engineering applications
Authors: Bhowmick A.
Pramanik N.
Mitra T.
Gnanamani A.
Das M.
Kundu, Patit Paban
Published in: New Journal of Chemistry
Abstract: ZrO2 nanoparticle (NP) doped CTS-PVA-HAP composites (ZrCPH I-III) were developed and characterized by FT-IR and XRD studies to mimic human bone for bone tissue engineering applications. Interconnected porous structures of these composites were observed via SEM and the porosities were in the range of human cancellous bone. These composites also have good swelling abilities both in aqueous and SBF media. The addition of ZrO2 NPs into the CTS-PVA-HAP composites improved the tensile strength of ZrCPH I-III compared with previously reported CTS-PVA-HAP composites, and the maximum tensile strength was obtained with ZrCPH III (CTS:PVA:HAP-ZrO2 = 55:30:15 wt%), which had the highest ZrO2 content (0.3 wt%). The strongest antimicrobial effect was also observed for ZrCPH III, which had the maximum amount of nano-HAP-ZrO2. Cytocompatibility with human osteoblastic MG-63 cells was also established and the highest cell proliferation was observed with ZrCPH III. Thus, ZrCPH III should have the potential to be applied as a bone tissue engineering material. © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2017.
Citation: New Journal of Chemistry (2017), 41(15): 7524-7530
URI: https://doi.org/10.1039/c7nj01246b
http://repository.iitr.ac.in/handle/123456789/2208
Issue Date: 2017
Publisher: Royal Society of Chemistry
ISSN: 11440546
Author Scopus IDs: 53986105300
56324545100
39863189900
6602667464
35585815900
35475516300
Author Affiliations: Bhowmick, A., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India
Pramanik, N., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India
Mitra, T., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India
Gnanamani, A., Microbiology Division, CSIR-Central Leather Research Institute, Adyar, Chennai, Tamil Nadu, 600020, India
Das, M., Department of Chemical Engineering, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India
Kundu, P.P., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India, Department of Chemical Engineering, Indian Institute of Technology, Roorkee, 247667, India
Corresponding Author: Kundu, P.P.; Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, India; email: ppk923@yahoo.com
Appears in Collections:Journal Publications [CH]

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