http://repository.iitr.ac.in/handle/123456789/2208
Title: | Mechanical and biological investigations of chitosan-polyvinyl alcohol based ZrO2 doped porous hybrid composites for bone tissue engineering applications |
Authors: | Bhowmick A. Pramanik N. Mitra T. Gnanamani A. Das M. Kundu, Patit Paban |
Published in: | New Journal of Chemistry |
Abstract: | ZrO2 nanoparticle (NP) doped CTS-PVA-HAP composites (ZrCPH I-III) were developed and characterized by FT-IR and XRD studies to mimic human bone for bone tissue engineering applications. Interconnected porous structures of these composites were observed via SEM and the porosities were in the range of human cancellous bone. These composites also have good swelling abilities both in aqueous and SBF media. The addition of ZrO2 NPs into the CTS-PVA-HAP composites improved the tensile strength of ZrCPH I-III compared with previously reported CTS-PVA-HAP composites, and the maximum tensile strength was obtained with ZrCPH III (CTS:PVA:HAP-ZrO2 = 55:30:15 wt%), which had the highest ZrO2 content (0.3 wt%). The strongest antimicrobial effect was also observed for ZrCPH III, which had the maximum amount of nano-HAP-ZrO2. Cytocompatibility with human osteoblastic MG-63 cells was also established and the highest cell proliferation was observed with ZrCPH III. Thus, ZrCPH III should have the potential to be applied as a bone tissue engineering material. © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2017. |
Citation: | New Journal of Chemistry (2017), 41(15): 7524-7530 |
URI: | https://doi.org/10.1039/c7nj01246b http://repository.iitr.ac.in/handle/123456789/2208 |
Issue Date: | 2017 |
Publisher: | Royal Society of Chemistry |
ISSN: | 11440546 |
Author Scopus IDs: | 53986105300 56324545100 39863189900 6602667464 35585815900 35475516300 |
Author Affiliations: | Bhowmick, A., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India Pramanik, N., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India Mitra, T., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India Gnanamani, A., Microbiology Division, CSIR-Central Leather Research Institute, Adyar, Chennai, Tamil Nadu, 600020, India Das, M., Department of Chemical Engineering, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India Kundu, P.P., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India, Department of Chemical Engineering, Indian Institute of Technology, Roorkee, 247667, India |
Corresponding Author: | Kundu, P.P.; Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, India; email: ppk923@yahoo.com |
Appears in Collections: | Journal Publications [CH] |
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