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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/2206
Title: Development of bone-like zirconium oxide nanoceramic modified chitosan based porous nanocomposites for biomedical application
Authors: Bhowmick A.
Pramanik N.
Jana P.
Mitra T.
Gnanamani A.
Das M.
Kundu, Patit Paban
Published in: International Journal of Biological Macromolecules
Abstract: Here, zirconium oxide nanoparticles (ZrO2 NPs) were incorporated for the first time in organic-inorganic hybrid composites containing chitosan, poly(ethylene glycol) and nano-hydroxypatite (CS-PEG-HA) to develop bone-like nanocomposites for bone tissue engineering application. These nanocomposites were characterized by FT-IR, XRD, TEM combined with SAED. SEM images and porosity measurements revealed highly porous structure having pore size of less than 1 ?m to 10 ?m. Enhanced water absorption capacity and mechanical strengths were obtained compared to previously reported CS-PEG-HA composite after addition of 0.1–0.3 wt% of ZrO2 NPs into these nanocomposites. The mechanical strengths and porosities were similar to that of human spongy bone. Strong antimicrobial effects against gram-negative and gram-positive bacterial strains were also observed. Along with getting low alkalinity pH (7.4) values, similar to the pH of human plasma, hemocompatibility and cytocompatibility with osteoblastic MG-63 cells were also established for these nanocomposites. Addition of 15 wt% HA-ZrO2 (having 0.3 wt% ZrO2 NPs) into CS-PEG (55:30 wt%) composite resulted in greatest mechanical strength, porosity, antimicrobial property and cytocompatibility along with suitable water absorption capacity and compatibility with human pH and blood. Thus, this nanocomposite could serve as a potential candidate to be used for bone tissue engineering. © 2016 Elsevier B.V.
Citation: International Journal of Biological Macromolecules (2017), 95(): 348-356
URI: https://doi.org/10.1016/j.ijbiomac.2016.11.052
http://repository.iitr.ac.in/handle/123456789/2206
Issue Date: 2017
Publisher: Elsevier B.V.
Keywords: Chitosan
Hydroxyapatite
Nanocomposites
Poly(ethylene glycol)
Zirconium oxide
ISSN: 1418130
Author Scopus IDs: 53986105300
56324545100
57102951300
39863189900
6602667464
35585815900
35475516300
Author Affiliations: Bhowmick, A., Department of Polymer Science and Technology, University of Calcutta, 92?A.P.C. Road, Kolkata, 700009, India
Pramanik, N., Department of Polymer Science and Technology, University of Calcutta, 92?A.P.C. Road, Kolkata, 700009, India
Jana, P., Department of Polymer Science and Technology, University of Calcutta, 92?A.P.C. Road, Kolkata, 700009, India
Mitra, T., Department of Polymer Science and Technology, University of Calcutta, 92?A.P.C. Road, Kolkata, 700009, India
Gnanamani, A., Microbiology Division, CSIR-Central Leather Research Institute, Adyar, Chennai, Tamil Nadu 600020, India
Das, M., Department of Chemical Engineering, University of Calcutta, 92?A.P.C. Road, Kolkata, 700009, India
Kundu, P.P., Department of Polymer Science and Technology, University of Calcutta, 92?A.P.C. Road, Kolkata, 700009, India, Department of Chemical Engineering, Indian Institute of Technology, Roorkee, 247667, India
Corresponding Author: Kundu, P.P.; Department of Polymer Science and Technology, University of Calcutta, 92?A.P.C. Road, India; email: ppk923@yahoo.com
Appears in Collections:Journal Publications [CH]

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