Skip navigation
Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/2203
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBhattacharyya A.-
dc.contributor.authorMukherjee D.-
dc.contributor.authorMishra R.-
dc.contributor.authorKundu, Patit Paban-
dc.date.accessioned2020-10-06T14:08:44Z-
dc.date.available2020-10-06T14:08:44Z-
dc.date.issued2017-
dc.identifier.citationEuropean Polymer Journal (2017), 92(): 294-313-
dc.identifier.issn143057-
dc.identifier.urihttps://doi.org/10.1016/j.eurpolymj.2017.05.015-
dc.identifier.urihttp://repository.iitr.ac.in/handle/123456789/2203-
dc.description.abstractWaste polyethylene terephthalate (PET) is depolymerized through glycolysis and the glycolyzed product, bis (2-hydroxyethylene) terephthalate (BHET) is utilized in the synthesis of polyurethane as diol. Polyurethane (PU) is incorporated in a core- shell nanoparticle formulation along with alginate (ALG) and chitosan (CS) to develop an efficient oral insulin delivery vehicle. Fourier transform infrared (FT-IR) spectrums of the polyurethane-alginate/chitosan (PU-ALG/CS) nanoparticles confirm the presence of all elements distinctly. Nanoparticles of average particle size 90–110 nm are clearly visible from the images of scanning electron microscope (SEM) and transmission electron microscope (TEM). Unique characteristics of insulin loaded PU-ALG/CS nanoparticles are noticed in both in vitro and in vivo studies. More than 90% insulin encapsulation efficiency, sustained swelling, controlled insulin release from mucoadhesive nanoparticle formulation are the major causes of long term hypoglycaemic effects in diabetic mice and improved insulin bioavailability (10.36%). PU-ALG/CS nanoparticles are also found to be safe, according to the acute toxicity studies. © 2017 Elsevier Ltd-
dc.language.isoen_US-
dc.publisherElsevier Ltd-
dc.relation.ispartofEuropean Polymer Journal-
dc.subjectChitosan-
dc.subjectCore-shell-
dc.subjectInsulin bioavailability-
dc.subjectNanoparticles-
dc.subjectPolyurethane-
dc.titlePreparation of polyurethane–alginate/chitosan core shell nanoparticles for the purpose of oral insulin delivery-
dc.typeArticle-
dc.scopusid56075861300-
dc.scopusid57209519299-
dc.scopusid25643271200-
dc.scopusid35475516300-
dc.affiliationBhattacharyya, A., Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India-
dc.affiliationMukherjee, D., Department of Physiology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India-
dc.affiliationMishra, R., Department of Physiology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India-
dc.affiliationKundu, P.P., Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India, Department of Chemical Engineering, Indian Institute of Technology, Roorkee, Uttarakhand, India-
dc.description.correspondingauthorKundu, P.P.; Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, India; email: ppk923@yahoo.com-
Appears in Collections:Journal Publications [CH]

Files in This Item:
There are no files associated with this item.
Show simple item record


Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.