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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/2203
Title: Preparation of polyurethane–alginate/chitosan core shell nanoparticles for the purpose of oral insulin delivery
Authors: Bhattacharyya A.
Mukherjee D.
Mishra R.
Kundu, Patit Paban
Published in: European Polymer Journal
Abstract: Waste polyethylene terephthalate (PET) is depolymerized through glycolysis and the glycolyzed product, bis (2-hydroxyethylene) terephthalate (BHET) is utilized in the synthesis of polyurethane as diol. Polyurethane (PU) is incorporated in a core- shell nanoparticle formulation along with alginate (ALG) and chitosan (CS) to develop an efficient oral insulin delivery vehicle. Fourier transform infrared (FT-IR) spectrums of the polyurethane-alginate/chitosan (PU-ALG/CS) nanoparticles confirm the presence of all elements distinctly. Nanoparticles of average particle size 90–110 nm are clearly visible from the images of scanning electron microscope (SEM) and transmission electron microscope (TEM). Unique characteristics of insulin loaded PU-ALG/CS nanoparticles are noticed in both in vitro and in vivo studies. More than 90% insulin encapsulation efficiency, sustained swelling, controlled insulin release from mucoadhesive nanoparticle formulation are the major causes of long term hypoglycaemic effects in diabetic mice and improved insulin bioavailability (10.36%). PU-ALG/CS nanoparticles are also found to be safe, according to the acute toxicity studies. © 2017 Elsevier Ltd
Citation: European Polymer Journal (2017), 92(): 294-313
URI: https://doi.org/10.1016/j.eurpolymj.2017.05.015
http://repository.iitr.ac.in/handle/123456789/2203
Issue Date: 2017
Publisher: Elsevier Ltd
Keywords: Chitosan
Core-shell
Insulin bioavailability
Nanoparticles
Polyurethane
ISSN: 143057
Author Scopus IDs: 56075861300
57209519299
25643271200
35475516300
Author Affiliations: Bhattacharyya, A., Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India
Mukherjee, D., Department of Physiology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India
Mishra, R., Department of Physiology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India
Kundu, P.P., Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India, Department of Chemical Engineering, Indian Institute of Technology, Roorkee, Uttarakhand, India
Corresponding Author: Kundu, P.P.; Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, India; email: ppk923@yahoo.com
Appears in Collections:Journal Publications [CH]

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