http://repository.iitr.ac.in/handle/123456789/2203
Title: | Preparation of polyurethane–alginate/chitosan core shell nanoparticles for the purpose of oral insulin delivery |
Authors: | Bhattacharyya A. Mukherjee D. Mishra R. Kundu, Patit Paban |
Published in: | European Polymer Journal |
Abstract: | Waste polyethylene terephthalate (PET) is depolymerized through glycolysis and the glycolyzed product, bis (2-hydroxyethylene) terephthalate (BHET) is utilized in the synthesis of polyurethane as diol. Polyurethane (PU) is incorporated in a core- shell nanoparticle formulation along with alginate (ALG) and chitosan (CS) to develop an efficient oral insulin delivery vehicle. Fourier transform infrared (FT-IR) spectrums of the polyurethane-alginate/chitosan (PU-ALG/CS) nanoparticles confirm the presence of all elements distinctly. Nanoparticles of average particle size 90–110 nm are clearly visible from the images of scanning electron microscope (SEM) and transmission electron microscope (TEM). Unique characteristics of insulin loaded PU-ALG/CS nanoparticles are noticed in both in vitro and in vivo studies. More than 90% insulin encapsulation efficiency, sustained swelling, controlled insulin release from mucoadhesive nanoparticle formulation are the major causes of long term hypoglycaemic effects in diabetic mice and improved insulin bioavailability (10.36%). PU-ALG/CS nanoparticles are also found to be safe, according to the acute toxicity studies. © 2017 Elsevier Ltd |
Citation: | European Polymer Journal (2017), 92(): 294-313 |
URI: | https://doi.org/10.1016/j.eurpolymj.2017.05.015 http://repository.iitr.ac.in/handle/123456789/2203 |
Issue Date: | 2017 |
Publisher: | Elsevier Ltd |
Keywords: | Chitosan Core-shell Insulin bioavailability Nanoparticles Polyurethane |
ISSN: | 143057 |
Author Scopus IDs: | 56075861300 57209519299 25643271200 35475516300 |
Author Affiliations: | Bhattacharyya, A., Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India Mukherjee, D., Department of Physiology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India Mishra, R., Department of Physiology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India Kundu, P.P., Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India, Department of Chemical Engineering, Indian Institute of Technology, Roorkee, Uttarakhand, India |
Corresponding Author: | Kundu, P.P.; Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, India; email: ppk923@yahoo.com |
Appears in Collections: | Journal Publications [CH] |
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