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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/2202
Title: Alginate coated chitosan core-shell nanoparticles for efficient oral delivery of naringenin in diabetic animals—An in vitro and in vivo approach
Authors: Maity S.
Mukhopadhyay P.
Kundu, Patit Paban
Chakraborti A.S.
Published in: Carbohydrate Polymers
Abstract: The chemical synthesis of this study targets for development of a bio-safe polymeric nano-vehicle for improvising the solubility of the flavanone naringenin in antidiabetic animal study. Nanoparticles were prepared from two cost-effective carbohydrate biopolymers – chitosan and alginate for successful encapsulation of naringenin. Dual crosslinked nanoparticles were synthesized by using Na2SO4 and CaCl2 as crosslinkers. The nanoparticles were characterized by DLS, FTIR, XRD and SEM. The prepared nano-formulations exhibited significant naringenin entrapment of >90% and pH-responsive slow and sustained release of the flavonoid. In-vivo studies revealed significant hypoglycemic effect after oral delivery of the nanoparticles to streptozotocin-induced diabetic rats. Histopathology and several blood parameters indicated that oral administrations of nanoparticles were free from toxicity. Other studies also suggested that polymeric formulations were quite effective for oral delivery of the flavonoid as a therapeutic agent in the treatment of dyslipidemia, hyperglycemia and haemoglobin iron-mediated oxidative stress in type 1 diabetic model. © 2017 Elsevier Ltd
Citation: Carbohydrate Polymers (2017), 170(): 124-132
URI: https://doi.org/10.1016/j.carbpol.2017.04.066
http://repository.iitr.ac.in/handle/123456789/2202
Issue Date: 2017
Publisher: Elsevier Ltd
Keywords: Alginate
Chitosan
Core-shell nanoparticles
Diabetes mellitus
Naringenin
Oral delivery
ISSN: 1448617
Author Scopus IDs: 56950056200
55235955100
35475516300
7005107569
Author Affiliations: Maity, S., Department of Biophysics, Molecular Biology and Bioinformatics, University College of Science, Kolkata, West Bengal 700009, India
Mukhopadhyay, P., Department of Polymer Science & Technology, University College of Science, Kolkata, West Bengal 700009, India
Kundu, P.P., Department of Polymer Science & Technology, University College of Science, Kolkata, West Bengal 700009, India, Department of Chemical Engineering, Indian Institute of Technology, Roorkee, 247667, India
Chakraborti, A.S., Department of Biophysics, Molecular Biology and Bioinformatics, University College of Science, Kolkata, West Bengal 700009, India
Corresponding Author: Chakraborti, A.S.; Department of Biophysics, Molecular Biology and Bioinformatics, University College of ScienceIndia; email: abhay_chakraborti@yahoo.co.in
Appears in Collections:Journal Publications [CH]

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