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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/2198
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dc.contributor.authorBhowmick A.-
dc.contributor.authorBanerjee S.L.-
dc.contributor.authorPramanik N.-
dc.contributor.authorJana P.-
dc.contributor.authorMitra T.-
dc.contributor.authorGnanamani A.-
dc.contributor.authorDas M.-
dc.contributor.authorKundu, Patit Paban-
dc.date.accessioned2020-10-06T14:08:43Z-
dc.date.available2020-10-06T14:08:43Z-
dc.date.issued2018-
dc.identifier.citationInternational Journal of Biological Macromolecules (2018), 106(): 11-19-
dc.identifier.issn1418130-
dc.identifier.other28774805-
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2017.07.168-
dc.identifier.urihttp://repository.iitr.ac.in/handle/123456789/2198-
dc.description.abstractThe objective of this study is to design biomimetic organically modified montmorillonite clay (OMMT) supported chitosan/hydroxyapatite-zinc oxide (CTS/HAP-ZnO) nanocomposites (ZnCMH I-III) with improved mechanical and biological properties compared to previously reported CTS/OMMT/HAP composite. Fourier transform infrared spectroscopy, powder X-ray diffraction, scanning electron microscopy and transmission electron microscopy were used to analyze the composition and surface morphology of the prepared nanocomposites. Strong antibacterial properties against both Gram-positive and Gram-negative bacterial strains were established for ZnCMH I-III. pH and blood compatibility study revealed that ZnCMH I-III should be nontoxic to the human body. Cytocompatibility of these nanocomposites with human osteoblastic MG-63 cells was also established. Experimental findings suggest that addition of 5 wt% of OMMT into CTS/HAP-ZnO (ZnCMH I) gives the best mechanical strength and water absorption capacity. Addition of 0.1 wt% of ZnO nanoparticles into CTS-OMMT-HAP significantly enhanced the tensile strengths of ZnCMH I-III compared to previously reported CTS-OMMT-HAP composite. In absence of OMMT, control sample (ZnCH) also showed reduced tensile strength, antibacterial effect and cytocompatibility with osteoblastic cell compared to ZnCMH I. Considering all of the above-mentioned studies, it can be proposed that ZnCMH I nanocomposite has a great potential to be applied in bone tissue engineering. © 2017 Elsevier B.V.-
dc.language.isoen_US-
dc.publisherElsevier B.V.-
dc.relation.ispartofInternational Journal of Biological Macromolecules-
dc.subjectChitosan-
dc.subjectOrganically modified montmorillonite-
dc.subjectZinc oxide-
dc.titleOrganically modified clay supported chitosan/hydroxyapatite-zinc oxide nanocomposites with enhanced mechanical and biological properties for the application in bone tissue engineering-
dc.typeArticle-
dc.scopusid53986105300-
dc.scopusid56424674800-
dc.scopusid56324545100-
dc.scopusid57102951300-
dc.scopusid39863189900-
dc.scopusid6602667464-
dc.scopusid35585815900-
dc.scopusid35475516300-
dc.affiliationBhowmick, A., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India-
dc.affiliationBanerjee, S.L., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India-
dc.affiliationPramanik, N., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India-
dc.affiliationJana, P., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India-
dc.affiliationMitra, T., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India-
dc.affiliationGnanamani, A., Microbiology Division, CSIR-Central Leather Research Institute, Adyar, Chennai, Tamil Nadu 600020, India-
dc.affiliationDas, M., Department of Chemical Engineering, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India-
dc.affiliationKundu, P.P., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India, Department of Chemical Engineering, Indian Institute of Technology, Roorkee, 247667, India-
dc.description.correspondingauthorKundu, P.P.; Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, India; email: ppk923@yahoo.com-
Appears in Collections:Journal Publications [CH]

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