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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/2198
Title: Organically modified clay supported chitosan/hydroxyapatite-zinc oxide nanocomposites with enhanced mechanical and biological properties for the application in bone tissue engineering
Authors: Bhowmick A.
Banerjee S.L.
Pramanik N.
Jana P.
Mitra T.
Gnanamani A.
Das M.
Kundu, Patit Paban
Published in: International Journal of Biological Macromolecules
Abstract: The objective of this study is to design biomimetic organically modified montmorillonite clay (OMMT) supported chitosan/hydroxyapatite-zinc oxide (CTS/HAP-ZnO) nanocomposites (ZnCMH I-III) with improved mechanical and biological properties compared to previously reported CTS/OMMT/HAP composite. Fourier transform infrared spectroscopy, powder X-ray diffraction, scanning electron microscopy and transmission electron microscopy were used to analyze the composition and surface morphology of the prepared nanocomposites. Strong antibacterial properties against both Gram-positive and Gram-negative bacterial strains were established for ZnCMH I-III. pH and blood compatibility study revealed that ZnCMH I-III should be nontoxic to the human body. Cytocompatibility of these nanocomposites with human osteoblastic MG-63 cells was also established. Experimental findings suggest that addition of 5 wt% of OMMT into CTS/HAP-ZnO (ZnCMH I) gives the best mechanical strength and water absorption capacity. Addition of 0.1 wt% of ZnO nanoparticles into CTS-OMMT-HAP significantly enhanced the tensile strengths of ZnCMH I-III compared to previously reported CTS-OMMT-HAP composite. In absence of OMMT, control sample (ZnCH) also showed reduced tensile strength, antibacterial effect and cytocompatibility with osteoblastic cell compared to ZnCMH I. Considering all of the above-mentioned studies, it can be proposed that ZnCMH I nanocomposite has a great potential to be applied in bone tissue engineering. © 2017 Elsevier B.V.
Citation: International Journal of Biological Macromolecules (2018), 106(): 11-19
URI: https://doi.org/10.1016/j.ijbiomac.2017.07.168
http://repository.iitr.ac.in/handle/123456789/2198
Issue Date: 2018
Publisher: Elsevier B.V.
Keywords: Chitosan
Organically modified montmorillonite
Zinc oxide
ISSN: 1418130
Author Scopus IDs: 53986105300
56424674800
56324545100
57102951300
39863189900
6602667464
35585815900
35475516300
Author Affiliations: Bhowmick, A., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India
Banerjee, S.L., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India
Pramanik, N., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India
Jana, P., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India
Mitra, T., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India
Gnanamani, A., Microbiology Division, CSIR-Central Leather Research Institute, Adyar, Chennai, Tamil Nadu 600020, India
Das, M., Department of Chemical Engineering, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India
Kundu, P.P., Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata, 700009, India, Department of Chemical Engineering, Indian Institute of Technology, Roorkee, 247667, India
Corresponding Author: Kundu, P.P.; Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, India; email: ppk923@yahoo.com
Appears in Collections:Journal Publications [CH]

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