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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/2195
Title: Preparation, characterization and in vivo evaluation of pH sensitive, safe quercetin-succinylated chitosan-alginate core-shell-corona nanoparticle for diabetes treatment
Authors: Mukhopadhyay P.
Maity S.
Mandal S.
Chakraborti A.S.
Prajapati A.K.
Kundu, Patit Paban
Published in: Carbohydrate Polymers
Abstract: The study aims for development of an efficient polymeric carrier for evaluating pharmaceutical potentialities in modulating the drug profile of quercetin (QUE) in anti-diabetic research. Alginate and succinyl chitosan are focused in this investigation for encapsulating quercetin into core-shell nanoparticles through ionic cross linking. The FT-IR, XRD, NMR, SEM, TEM, drug entrapment and loading efficiency are commenced to examine the efficacy of the prepared nanoparticles in successful quercetin delivery. Obtained results showed the minimum particle size of ?91.58 nm and ?95% quercetin encapsulation efficiently of the particles with significant pH sensitivity. Kinetics of drug release suggested self-sustained QUE release following the non-fickian trend. A pronounced hypoglycaemic effect and efficient maintenance of glucose homeostasis was evident in diabetic rat after peroral delivery of these quercetin nanoparticles in comparison to free oral quercetin. This suggests the fabrication of an efficient carrier of oral quercetin for diabetes treatment. © 2017 Elsevier Ltd
Citation: Carbohydrate Polymers (2018), 182(): 42-51
URI: https://doi.org/10.1016/j.carbpol.2017.10.098
http://repository.iitr.ac.in/handle/123456789/2195
Issue Date: 2018
Publisher: Elsevier Ltd
Keywords: Alginate
Core-shell nanoparticles
Diabetes treatment
Quercetin delivery
Succinyl chitosan
ISSN: 1448617
Author Scopus IDs: 55235955100
56950056200
57196389932
7005107569
21739759300
35475516300
Author Affiliations: Mukhopadhyay, P., Department of Chemistry, Faculty of Science, The M. S. University of Baroda, Vadodara, 390 002, India
Maity, S., Department of Bio-Physics, Molecular Biology and Bioinformatics, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India
Mandal, S., Division of Biochemistry, NICED, Kolkata, India
Chakraborti, A.S., Department of Bio-Physics, Molecular Biology and Bioinformatics, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India
Prajapati, A.K., Department of Chemistry, Faculty of Science, The M. S. University of Baroda, Vadodara, 390 002, India
Kundu, P.P., Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India, Department of Chemical Engineering, Indian Institute of Technology, Roorkee, 247667, India
Funding Details: Dr. Piyasi Mukhopadhyay greatly appreciates and acknowledges financial support under Dr. D. S. Kothari Postdoctoral fellowship [No. F.4-2/2006(BSR)/CH/14-15/0082, Dated: March 2015] funded by the UGC, New Delhi, India . Mr. Subhajit Maity acknowledges UGC, Government of India for financial assistance (UGC/58/Jr.Fellow(Sc) dated 25. 01 0.2012). The authors are highly thankful to Prof N. D. Kulkarni, Head, Dept. of Chemistry, The M. S. University of Baroda, for providing laboratory and instrumental facilities. Authors wish to thank Prof. N. S. Chatterjee, Scientist- E, Division of Biochemistry, NICED, Kolkata for his cooperation for conducting in vitro cellular uptake studies and Prof. Swati Bhattacharya, for microscopic imaging in Bose Institute, Kolkata. Mr. Pratyush Sengupta and Mrs. Urmila Goswami, University of Calcutta, are acknowledged for conducting SEM and TEM imaging. Appendix A
Corresponding Author: Prajapati, A.K.; Department of Chemistry, Faculty of Science, The M. S. University of BarodaIndia; email: akprajapati@yahoo.co.uk
Appears in Collections:Journal Publications [CH]

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