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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/2191
Title: Polyurethane-incorporated chitosan/alginate core–shell nano-particles for controlled oral insulin delivery
Authors: Bhattacharyya A.
Nasim F.
Mishra R.
Bharti, Ram Prakash
Kundu, Patit Paban
Published in: Journal of Applied Polymer Science
Abstract: Chitosan (CS) and polyurethane-chitosan (PU-CS) nano-particles (NPs) were prepared for the core formation by complex coacervation method whereas alginate (ALG) and PU-ALG were crosslinked by ionic gelation method to form the protective shell-layer over the core. Effects of PU incorporation either within the core or shell or both were investigated by different in vitro and in vivo parameters. Fourier transform infrared (FTIR) spectroscopy of different compositions of nano-particles showed distinct characteristic peaks for CS, PU, and ALG, indicating their presence in variable ratios. Significance of polyurethane-incorporated systems towards insulin encapsulation efficiency, swelling parameters, insulin release, and in vivo pharmacological effect were also studied. Particle sizes, zeta potential, morphological analysis, mucoadhesion study, and in vivo acute toxicity studies of these core–shell nano-particles were also performed. Bioavailability of insulin ranged from 9.04% to 11.6% for polyurethane-incorporated chitosan-alginate core–shell nano-particle formulations which was significantly higher than the insulin bioavailability of basic CS/ALG core–shell nano-particle system. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46365. © 2018 Wiley Periodicals, Inc.
Citation: Journal of Applied Polymer Science (2018), 135(26): -
URI: https://doi.org/10.1002/app.46365
http://repository.iitr.ac.in/handle/123456789/2191
Issue Date: 2018
Publisher: John Wiley and Sons Inc.
Keywords: biomaterials
biopolymers and renewable polymers
drug delivery systems
nanoparticles
polyurethane
ISSN: 218995
Author Scopus IDs: 56075861300
57194406463
25643271200
14521775900
35475516300
Author Affiliations: Bhattacharyya, A., Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India
Nasim, F., Department of Physiology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India
Mishra, R., Department of Physiology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India
Bharti, R.P., Department of Chemical Engineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand 247667, India
Kundu, P.P., Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India, Department of Chemical Engineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand 247667, India
Funding Details: We are intensely thankful to Department of Science and Technology, Government of India for their financial support utilized for this work and the project entitled ‘Development of Polyurethane vehicle based on poly(ethylene terephthalate) (PET) waste for controlled protein drug delivery’; Sanction No: DST/DISHA/SoRF-PM/045/2013
Corresponding Author: Kundu, P.P.; Department of Polymer Science and Technology, University of Calcutta, 92, A.P.C. Road, India; email: ppk923@yahoo.com
Appears in Collections:Journal Publications [CH]

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