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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/2185
Title: Polyhydroxybutyrate-co-hydroxyvalerate copolymer modified graphite oxide based 3D scaffold for tissue engineering application
Authors: Pramanik N.
Bhattacharya S.
Rath T.
De J.
Adhikary A.
Basu R.K.
Kundu P.P.
Published in: Materials Science and Engineering C
Abstract: In this study, we have fabricated the PHBV functionalized graphite oxide using freeze drying technique, followed by ‘in situ’ pay loading of Fe3O4 nanoparticles onto the hydrophobic plate of the composite basal plane; thereby, mechanically and thermally stable, bio-imaging Fe3O4/GO-g-PHBV composites have been developed. The synthesis of Fe3O4/GO-g-PHBV composite was confirmed by field emission SEM and TEM analyses, X-ray diffraction and Fourier transform infrared spectroscopy. The wrapping of PHBV copolymer into the graphene layers was investigated by atomic force microscopy and Raman spectral analyses which provided the shifting of the 2D band with low signal intensity in the range of 2600–3000 cm?1. The bactericidal activities of the Fe3O4/GO-g-PHBV composite films were found to exhibit more efficiency against Gram-negative bacteria strains compared to Gram-positive strains. In vibrating sample magnetometer (VSM) analysis, the zero value of coercivity revealed the super-paramagnetic nature of the Fe3O4/GO-g-PHBV composites. The Phantom agar magnetic resonance imaging analysis revealed the efficiency of Fe3O4 nanoparticles as a negative contrast (T2 contrast) along with higher relaxivity value. The significant fibroblast cell (NIH 3T3) adhesion and proliferation (85%) on the Fe3O4/GO-g-PHBV composite surface indicated the physiological and biocompatible stability of that composite along with the presence of large ? conjugated aromatic domain. © 2018 Elsevier B.V.
Citation: Materials Science and Engineering C (2019), 94(): 534-546
URI: https://doi.org/10.1016/j.msec.2018.10.009
http://repository.iitr.ac.in/handle/123456789/2185
Issue Date: 2019
Publisher: Elsevier Ltd
Keywords: Biocompatibility
Biodegradability
Graphite oxide
MRI imaging
Tissue engineering
ISSN: 9284931
Author Scopus IDs: 56324545100
55451791800
14829487300
57189458182
15727299000
7101688201
35475516300
Author Affiliations: Pramanik, N., Department of Polymer Science & Technology, University of CalcuttaWest Bengal 700073, India
Bhattacharya, S., Centre for Research in Nanoscience and Nanotechnology, University of Calcutta, JD-2, Sector III, Salt Lake, Kolkata, West Bengal 700098, India
Rath, T., Motihari College of Engineering, Motihari (Aryabhatta Knowledge University)Bihar 845401, India
De, J., Department of Radiodiagnosis, Nil Ratan Sirkar Hospital and Medical CollegeWest Bengal 700014, India
Adhikary, A., Centre for Research in Nanoscience and Nanotechnology, University of Calcutta, JD-2, Sector III, Salt Lake, Kolkata, West Bengal 700098, India
Basu, R.K., Department of Chemical Engineering, University of CalcuttaWest Bengal 700073, India
Kundu, P.P., Department of Polymer Science & Technology, University of CalcuttaWest Bengal 700073, India, Department of Chemical Engineering, Indian Institute of Technology (IIT) RoorkeeUttarakhand 247667, India
Funding Details: The authors gratefully acknowledge University Grant Commission (UGC, WES-5925 ), and Department of Science and Technology (DST, SERB-PDF/2016/001685 ), Government of India for their financial support in this experimental work.
Corresponding Author: Kundu, P.P.; Department of Polymer Science & Technology, University of CalcuttaIndia; email: ppk9233@yahoo.com
Appears in Collections:Journal Publications [CH]

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