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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/2180
Title: Curcumin entrapped gelatin/ionically modified bacterial cellulose based self-healable hydrogel film: An eco-friendly sustainable synthesis method of wound healing patch
Authors: Khamrai M.
Banerjee S.L.
Paul S.
Samanta S.
Kundu, Patit Paban
Published in: International Journal of Biological Macromolecules
Abstract: In this context, we have prepared a biocompatible gelatin based polyelectrolyte hydrogel patch that has an inherent ability to self-heal in the presence of physiological pH (pH = 7.4). The gelatin-based hydrogel patch consists of the ionically modified self-assembled bacterial cellulose (iBC), extracted from Glucanoacetobacter xylinus (MTCC7795) bacterial strain. Presence of the iBC provides a sturdy cage to the gelatin matrix and also participates into the self-healing activity via formation of the ionic interlocking system in the presence of buffer solution having a pH of 7.4 after being damaged. The self-healing activity of the patch has been monitored through tensile strength measurement and AFM depth profilometry analyses. Loading of the curcumin in the hydrogel patch system incorporates the wound healing activity, examined over the NIH 3 T3 fibroblast cell line. The patch is also able to show antimicrobial activity which has been assessed via FESEM analysis and live-dead assay using propidium iodide (PI) and 4?,6-diamidino-2-phenylindole (DAPI) as a fluorescent indicator. This self-healable, ionically interlocked, mechanically robust, bio-derived smart hydrogel patch system can pave a new direction in the transdermal drug delivery system. © 2018 Elsevier B.V.
Citation: International Journal of Biological Macromolecules (2019), 122(): 940-953
URI: https://doi.org/10.1016/j.ijbiomac.2018.10.196
http://repository.iitr.ac.in/handle/123456789/2180
Issue Date: 2019
Publisher: Elsevier B.V.
Keywords: Antimicrobial activity
Bacterial cellulose
Drug delivery
Patch
Polyelectrolyte hydrogel
Wound healing
ISSN: 1418130
Author Scopus IDs: 56641668300
56424674800
56464610400
57211801396
35475516300
Author Affiliations: Khamrai, M., Advanced Polymer Laboratory, Department of Polymer Science & Technology, University of Calcutta, 92 A. P. C. Road, Kolkata, 700009, India
Banerjee, S.L., Advanced Polymer Laboratory, Department of Polymer Science & Technology, University of Calcutta, 92 A. P. C. Road, Kolkata, 700009, India
Paul, S., Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India
Samanta, S., Advanced Polymer Laboratory, Department of Polymer Science & Technology, University of Calcutta, 92 A. P. C. Road, Kolkata, 700009, India
Kundu, P.P., Advanced Polymer Laboratory, Department of Polymer Science & Technology, University of Calcutta, 92 A. P. C. Road, Kolkata, 700009, India, Department of Chemical Engineering, Indian Institute of Technology (IIT) RoorkeeUttarakhand, India
Corresponding Author: Kundu, P.P.; Advanced Polymer Laboratory, Department of Polymer Science & Technology, University of Calcutta, 92 A. P. C. Road, India; email: ppk923@yahoo.com
Appears in Collections:Journal Publications [CH]

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