Skip navigation
Please use this identifier to cite or link to this item:
Title: Self-assembly of a Sequence-shuffled Short Peptide Amphiphile Triggered by Metal Ions into Terraced Nanodome-like Structures
Authors: Singh R.
Mishra N.K.
Gupta, Puneet
Joshi K.B.
Published in: Chemistry - An Asian Journal
Abstract: We highlight the structural diversity of strategically designed two short peptide amphiphiles (sPAs) and describe their structure–function relationship studies. The shuffling of two key amino acids, that is, tyrosine and phenylalanine, in a designed sPA lead to a pair of constitutional isomers. Such small and strategic alteration can bring a substantial change in the self-assembling pattern. Inspired from the naturally occurring metallopeptides, bioactive transition-metal ions were used for constructing the unusual nanostructures. Use of appropriate metal ions created bigger differences between the properties of these isomers and hence the self-assembly. Coordination of appropriate transition metal ions modifies the internal nanoscale structures of sPA, thus leading to the formation of vertically stacked terraced layers with decreasing size, which possess a high degree of dimensional regularity. We propose that such metal-induced terraced nanodome-like hierarchical self-assembly may have relevance for specific biotechnology applications. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Citation: Chemistry - An Asian Journal, 15(4): 531-539
Issue Date: 2020
Publisher: John Wiley and Sons Ltd
Keywords: Metal ions
Short peptide amphiphile
Terraced nanodome
ISSN: 18614728
Author Scopus IDs: 57202327064
Author Affiliations: Singh, R., Department of Chemistry, School of Chemical Science and Technology, Dr. Harisingh Gour Central University, Sagar, MP, 470003, India
Mishra, N.K., Indian Institute of Technology, Kanpur, 208016, India, Department of Chemistry, University of Copenhagen, Thorvaldsensvej 40, Frederiksberg C, 1871, Denmark
Gupta, P., Department of Chemistry, Indian Institute of Technology, Roorkee, 247667, India
Joshi, K.B., Department of Chemistry, School of Chemical Science and Technology, Dr. Harisingh Gour Central University, Sagar, MP, 470003, India
Funding Details: RS and NKM thank to CSIR-UGC for pre-doctoral senior research fellowship. RS and NKM contributed equally to this work. We acknowledge Sophisticated Instrument Centre (SIC)-Dr. Harisingh Gour Central University Sagar, India for AFM, TEM and SEM facility. Prof. Sandeep Verma IIT-Kanpur greatly acknowledge for his invaluable support during this work. This work is supported by CSIR-India project no. 02(0238)/15/EMR-II to KBJ.
Corresponding Author: Joshi, K.B.; Department of Chemistry, India; email:
Appears in Collections:Journal Publications [CY]

Files in This Item:
There are no files associated with this item.
Show full item record

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.