http://repository.iitr.ac.in/handle/123456789/20727| Title: | Transition metal ions induced secondary structural transformation in a hydrophobized short peptide amphiphile |
| Authors: | Singh R. Mishra N.K. Singh N. Rawal P. Gupta, Puneet Joshi K.B. |
| Published in: | New Journal of Chemistry |
| Abstract: | The precise control over self-assembling structures created by a rationally designed hydrophobized short peptide amphiphile (sPA) was studied. Bioactive transition metal ions were used to transform the supramolecular structures of this sPA. We aimed to understand the role of different transition metal ions in modulating the self-assembly of the sPAs. The presence and contribution of various secondary structures were quantitatively studied by Fourier transform infrared (FT-IR) spectroscopy, which corresponded well with microscopy observations and was further supported by computational methods. The rational incorporation of di-phenylalanine in a previously designed sPA sequence was the new addition to the sequentially studied sPAs and represents another method of alteration that can impart data regarding ion-responsive behavior to the self-assembly process. Such an approach will contribute to the design and development of stimuli-responsive novel biomaterials for numerous applications. © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2020. |
| Citation: | New Journal of Chemistry, 44(22): 9255-9263 |
| URI: | https://doi.org/10.1039/d0nj01501f http://repository.iitr.ac.in/handle/123456789/20727 |
| Issue Date: | 2020 |
| Publisher: | Royal Society of Chemistry |
| Keywords: | Amino acids Amphiphiles Fourier transform infrared spectroscopy Metal ions Peptides Transition metals Design and Development Fourier transform infra red (FTIR) spectroscopy Responsive behaviors Secondary structural transformation Secondary structures Self assembly process Self-assembling structure Supramolecular structure Transition metal compounds amphophile biomaterial phenylalanine transition element Article chemical structure conformational transition deconvolution density functional theory Fourier transform infrared spectroscopy hydrogen bond hydrophobicity magnetic field mathematical computing microscopy molecular interaction priority journal quantitative analysis scanning electron microscopy supramolecular chemistry ultraviolet radiation |
| ISSN: | 11440546 |
| Author Scopus IDs: | 57202327064 55940313800 56404762800 57217096933 57215231630 14058159300 |
| Author Affiliations: | Singh, R., Department of Chemistry, School of Chemical Science and Technology, Dr Harisingh Gour Central University, Sagar, MP 470003, India Mishra, N.K., Department of Chemistry, Indian Institute of Technology, Kanpur, India Singh, N., Department of Chemistry, Indian Institute of Technology, Kanpur, India Rawal, P., Department of Chemistry, Indian Institute of Technology, Roorkee, 247667, India Gupta, P., Department of Chemistry, Indian Institute of Technology, Roorkee, 247667, India Joshi, K.B., Department of Chemistry, School of Chemical Science and Technology, Dr Harisingh Gour Central University, Sagar, MP 470003, India |
| Funding Details: | RS, NKM, and NS thank CSIR-UGC and UGC for pre-doctoral senior research fellowships. PR thanks CSIR for JRF. We acknowledge Sophisticated Instrument Centre (SIC) – Dr Harisingh Gour Central University, Sagar, India for AFM and the Indian Institute of Technology (IIT) Roorkee for the computational facilities. Prof. Sandeep Verma IIT-Kanpur is greatly acknowledged for his invaluable support during this work. This work is supported by CSIR-India project no. 02(0238)/15/EMR-II to KBJ and Faculty Initiation Grant-IITR to PG. 02(0238)/15/EMR-II; Council of Scientific and Industrial Research, India, CSIR; University Grants Committee, UGC; Indian Institute of Technology Mandi, IIT |
| Corresponding Author: | Joshi, K.B.; Department of Chemistry, India; email: kbjoshi77@gmail.com |
| Appears in Collections: | Journal Publications [CY] |
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