Skip navigation
Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/20606
Title: A facile access to novel heterocyclic analogues of chalcone from newly synthesized ketone containing isoxazole and a benzoxazinone ring
Authors: Verma N.
Kumar S.
Ahmed, Naseem
Published in: RSC Advances
Abstract: A series of novel heterocyclic analogs of chalcone containing isoxazole and a benzoxazinone ring as a prime motif was rationally designed and synthesized. There is nothing in the literature about such α,β-unsaturated ketones. These compounds were synthesized using a Claisen-Schmidt condensation reaction of the ketone precursor with different aromatic aldehydes using ethanol as solvent and piperidine as a base. Our procedure offers easy access to isoxazole and benzoxazinone based chalcone derivatives providing yields in the range of 81-93% within 16 min under mild conditions. Out of 21, 11 compounds were screened for their antibacterial activities. Among the screened compounds, compounds 5aj, 5ak and 5bj showed excellent antibacterial activities with MIC: 0.34, 0.59 and 0.74 mg ml-1 respectively as compared to standard drugs. © 2016 The Royal Society of Chemistry.
Citation: RSC Advances, 6(56): 51183-51191
URI: https://doi.org/10.1039/c6ra08710h
http://repository.iitr.ac.in/handle/123456789/20606
Issue Date: 2016
Publisher: Royal Society of Chemistry
Keywords: Ketones
Organic compounds
Organic solvents
Synthesis (chemical)
Anti-bacterial activity
Aromatic aldehyde
Chalcone derivatives
Chalcones
Claisen Schmidt condensation
Facile access
Isoxazoles
Unsaturated ketones
Condensation reactions
ISSN: 20462069
Author Scopus IDs: 56666842900
56167238700
7401846814
Author Affiliations: Verma, N., Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, 247667, India
Kumar, S., Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, 247667, India
Ahmed, N., Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, 247667, India
Corresponding Author: Verma, N.; Department of Chemistry, India; email: nishant.sailove@gmail.com
Appears in Collections:Journal Publications [CY]

Files in This Item:
There are no files associated with this item.
Show full item record


Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.