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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/20234
Title: Host cell and SARS-CoV-2-associated molecular structures and factors as potential therapeutic targets
Authors: Chaudhary J.K.
Yadav R.
Chaudhary P.K.
Maurya A.
Roshan R.
Azam F.
Mehta J.
Handu S.
Prasad, Ramasare A.
Jain N.
Pandey A.K.
Dhamija P.
Published in: Cells
Abstract: Coronavirus disease 19 (COVID-19) is caused by an enveloped, positive-sense, single-stranded RNA virus, referred to as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which belongs to the realm Riboviria, order Nidovirales, family Coronaviridae, genus Betacoronavirus and the species Severe acute respiratory syndrome-related coronavirus. This viral disease is characterized by a myriad of varying symptoms, such as pyrexia, cough, hemoptysis, dyspnoea, diarrhea, muscle soreness, dysosmia, lymphopenia and dysgeusia amongst others. The virus mainly infects humans, various other mammals, avian species and some other companion livestock. SARS-CoV-2 cellular entry is primarily accomplished by molecular interaction between the virus’s spike (S) protein and the host cell surface receptor, angiotensin-converting enzyme 2 (ACE2), although other host cell-associated receptors/factors, such as neuropilin 1 (NRP-1) and neuropilin 2 (NRP-2), C-type lectin receptors (CLRs), as well as proteases such as TMPRSS2 (transmembrane serine protease 2) and furin, might also play a crucial role in infection, tropism and pathogenesis and clinical outcome. Furthermore, several structural and non-structural proteins of the virus themselves are very critical in determining the clinical outcome following infection. Considering such critical role(s) of the abovementioned host cell receptors, associated proteases/factors and virus structural/non-structural proteins (NSPs), it may be quite prudent to therapeutically target them through a multipronged clinical regimen to combat the disease. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Citation: Cells, 10(9)
URI: https://doi.org/10.3390/cells10092427
http://repository.iitr.ac.in/handle/123456789/20234
Issue Date: 2021
Publisher: MDPI
Keywords: Angiotensin-converting enzyme 2
Coronavirus disease 19
Pathogenesis
SARS-CoV-2
Therapeutic targeting
ISSN: 20734409
Author Scopus IDs: 55911511500
57217382672
57223206723
57275520900
57275521000
25638543300
57275571600
6603034292
16690394400
57192558036
57212028451
55404598300
Author Affiliations: Chaudhary, J.K., Department of Zoology, Shivaji College, University of Delhi, New Delhi, 110027, India
Yadav, R., Department of Pharmacology, All India Institute of Medical Sciences (AIIMS), Rishikesh, 249201, India
Chaudhary, P.K., Molecular Biology & Proteomics Laboratory, Department of Biotechnology, Indian Institute of Technology (IIT), Roorkee, 247667, India
Maurya, A., Department of Botany, Shivaji College, University of Delhi, New Delhi, 110027, India
Roshan, R., Department of Zoology, Shivaji College, University of Delhi, New Delhi, 110027, India
Azam, F., Department of Pharmaceutical Chemistry and Pharmacognosy, Unaizah College of Pharmacy, Qassim University, Unaizah, 51911, Saudi Arabia
Mehta, J., Department of Physiology, Maharishi Markandeshwar Medical College and Hospital, Solan, 173229, India
Handu, S., Department of Pharmacology, All India Institute of Medical Sciences (AIIMS), Rishikesh, 249201, India
Prasad, R., Molecular Biology & Proteomics Laboratory, Department of Biotechnology, Indian Institute of Technology (IIT), Roorkee, 247667, India
Jain, N., Department of Cancer Biology, CSIR-Central Drug Research Institute, Lucknow, 226031, India
Pandey, A.K., Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India
Dhamija, P., Department of Pharmacology, All India Institute of Medical Sciences (AIIMS), Rishikesh, 249201, India
Corresponding Author: Yadav, R.; Department of Pharmacology, India; email: rohitashyadav1@gmail.com Dhamija, P.; Department of Pharmacology, India; email: drpdhamija@gmail.com
Appears in Collections:Journal Publications [BT]

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