Skip navigation
Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/20232
Title: Insights into covid-19 vaccine development based on immunogenic structural proteins of sars-cov-2, host immune responses, and herd immunity
Authors: Chaudhary J.K.
Yadav R.
Chaudhary P.K.
Maurya A.
Kant N.
Rugaie O.A.I.
Haokip H.R.
Yadav D.
Roshan R.
Prasad, Ramasare A.
Chatrath A.
Singh D.
Jain N.
Dhamija P.
Published in: Cells
Abstract: The first quarter of the 21st century has remarkably been characterized by a multitude of challenges confronting human society as a whole in terms of several outbreaks of infectious viral diseases, such as the 2003 severe acute respiratory syndrome (SARS), China; the 2009 influenza H1N1, Mexico; the 2012 Middle East respiratory syndrome (MERS), Saudi Arabia; and the ongoing coronavirus disease 19 (COVID-19), China. COVID-19, caused by SARS-CoV-2, reportedly broke out in December 2019, Wuhan, the capital of China’s Hubei province, and continues unabated, leading to considerable devastation and death worldwide. The most common target organ of SARS-CoV-2 is the lungs, especially the bronchial and alveolar epithelial cells, culminating in acute respiratory distress syndrome (ARDS) in severe patients. Nevertheless, other tissues and organs are also known to be critically affected following infection, thereby complicating the overall aetiology and prognosis. Excluding H1N1, the SARS-CoV (also referred as SARS-CoV-1), MERS, and SARS-CoV-2 are collectively referred to as coronaviruses, and taxonomically placed under the realm Riboviria, order Nidovirales, suborder Cornidovirineae, family Coronaviridae, subfamily Orthocoronavirinae, genus Betacoronavirus, and subgenus Sarbecovirus. As of 23 September 2021, the ongoing SARS-CoV-2 pandemic has globally resulted in around 229 million and 4.7 million reported infections and deaths, respectively, apart from causing huge psychosomatic debilitation, academic loss, and deep economic recession. Such an unprecedented pandemic has compelled researchers, especially epidemiologists and immunologists, to search for SARS-CoV-2-associated potential immunogenic molecules to develop a vaccine as an immediate prophylactic measure. Amongst multiple structural and nonstructural proteins, the homotrimeric spike (S) glycoprotein has been empirically found as the most suitable candidate for vaccine development owing to its immense immunogenic potential, which makes it capable of eliciting both humoral and cell-mediated immune responses. As a consequence, it has become possible to design appropriate, safe, and effective vaccines, apart from related therapeutic agents, to reduce both morbidity and mortality. As of 23 September 2021, four vaccines, namely, Comirnaty, COVID-19 vaccine Janssen, Spikevax, and Vaxzevria, have received the European Medicines Agency’s (EMA) approval, and around thirty are under the phase three clinical trial with emergency authorization by the vaccine-developing country-specific National Regulatory Authority (NRA). In addition, 100–150 vaccines are under various phases of pre-clinical and clinical trials. The mainstay of global vaccination is to introduce herd immunity, which would protect the majority of the population, including immunocompromised individuals, from infection and disease. Here, we primarily discuss category-wise vaccine development, their respective advantages and disadvantages, associated efficiency and potential safety aspects, antigenicity of SARS-CoV-2 structural proteins and immune responses to them along with the emergence of SARS-CoV-2 VOC, and the urgent need of achieving herd immunity to contain the pandemic. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Citation: Cells, 10(11)
URI: https://doi.org/10.3390/cells10112949
http://repository.iitr.ac.in/handle/123456789/20232
Issue Date: 2021
Publisher: MDPI
Keywords: Coronavirus disease 19
Herd immunity
Immune response
Infectious disease
Pandemic
SARS-CoV-2
Vaccination
ISSN: 20734409
Author Scopus IDs: 55911511500
57217382672
57223206723
57275520900
57204579703
57219281717
57218990193
57330026200
57275521000
16690394400
57195521729
57203808643
57192558036
55404598300
Author Affiliations: Chaudhary, J.K., Department of Zoology, Shivaji College, University of Delhi, New Delhi, 110027, India
Yadav, R., Department of Pharmacology, All India Institute of Medical Sciences (AIIMS), Rishikesh, 249201, India
Chaudhary, P.K., Molecular Biology & Proteomics Laboratory, Department of Biotechnology, Indian Institute of Technology (IIT), Roorkee, 247667, India
Maurya, A., Department of Botany, Shivaji College, University of Delhi, New Delhi, 110027, India
Kant, N., Department of Zoology, Shivaji College, University of Delhi, New Delhi, 110027, India
Rugaie, O.A.I., Department of Basic Medical Sciences, Unaizah College of Medicine and Medical Sciences, Qassim Uniersity, Unaizah, 51911, Saudi Arabia
Haokip, H.R., Medical Allied ICU, All India Institute of Medical Sciences, Rishikesh, 249201, India
Yadav, D., Department of Zoology, Shivaji College, University of Delhi, New Delhi, 110027, India
Roshan, R., Department of Zoology, Shivaji College, University of Delhi, New Delhi, 110027, India
Prasad, R., Molecular Biology & Proteomics Laboratory, Department of Biotechnology, Indian Institute of Technology (IIT), Roorkee, 247667, India
Chatrath, A., Molecular Biology & Proteomics Laboratory, Department of Biotechnology, Indian Institute of Technology (IIT), Roorkee, 247667, India
Singh, D., Molecular Biology & Proteomics Laboratory, Department of Biotechnology, Indian Institute of Technology (IIT), Roorkee, 247667, India
Jain, N., Department of Cancer Biology, CSIR-Central Drug Research Institute, Lucknow, 226031, India
Dhamija, P., Department of Pharmacology, All India Institute of Medical Sciences (AIIMS), Rishikesh, 249201, India
Funding Details: Acknowledgments: P.K.C. acknowledges J.R.F./S.R.F. from the Indian Council of Medical Research (ICMR), and the research facility availed at the Molecular Biology & Proteomics Laboratory, Department of Biotechnology, Indian Institute of Technology (IIT), Roorkee. R.Y. acknowledges the Junior Research Fellowship, and the research facility availed at the Department of Pharmacology, All India Institute of Medical Sciences (AIIMS), Rishikesh, India. A.M acknowledges the Department of Botany, Shivaji College, University of Delhi. J.K.C., N.K., D.Y., and R.R. acknowledge the Department of Zoology, Shivaji College, University of Delhi. Indian Council of Medical Research, ICMR; All-India Institute of Medical Sciences, AIIMS
Corresponding Author: Yadav, R.; Department of Pharmacology, India; email: rohitashyadav1@gmail.com Dhamija, P.; Department of Pharmacology, India; email: drpdhamija@gmail.com
Appears in Collections:Journal Publications [BT]

Files in This Item:
There are no files associated with this item.
Show full item record


Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.