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Title: Neurodegeneration & imperfect ageing: Technological limitations and challenges?
Authors: Sundaria N.
Upadhyay A.
Prasad A.
Prajapati V.K.
Poluri, Krishna Mohan
Mishra A.
Published in: Mechanisms of Ageing and Development
Abstract: Cellular homeostasis is regulated by the protein quality control (PQC) machinery, comprising multiple chaperones and enzymes. Studies suggest that the loss of the PQC mechanisms in neurons may lead to the formation of abnormal inclusions that may lead to neurological disorders and defective aging. The questions could be raised how protein aggregate formation precisely engenders multifactorial molecular pathomechanism in neuronal cells and affects different brain regions? Such questions await thorough investigation that may help us understand how aberrant proteinaceous bodies lead to neurodegeneration and imperfect aging. However, these studies face multiple technological challenges in utilizing available tools for detailed characterizations of the protein aggregates or amyloids and developing new techniques to understand the biology and pathology of proteopathies. The lack of detection and analysis methods has decelerated the pace of the research in amyloid biology. Here, we address the significance of aggregation and inclusion formation, followed by exploring the evolutionary contribution of these structures. We also provide a detailed overview of current state-of-the-art techniques and advances in studying amyloids in the diseased brain. A comprehensive understanding of the structural, pathological, and clinical characteristics of different types of aggregates (inclusions, fibrils, plaques, etc.) will aid in developing future therapies. © 2021 Elsevier B.V.
Citation: Mechanisms of Ageing and Development, 200
Issue Date: 2021
Publisher: Elsevier Ireland Ltd
Keywords: Amyloidosis
Protein aggregation
ISSN: 476374
Author Scopus IDs: 57202338704
Author Affiliations: Sundaria, N., Cellular and Molecular Neurobiology Unit, Indian Institute of Technology, Jodhpur, Rajasthan 342037, India
Upadhyay, A., Cellular and Molecular Neurobiology Unit, Indian Institute of Technology, Jodhpur, Rajasthan 342037, India
Prasad, A., School of Basic Sciences, Indian Institute of Technology Mandi, Mandi, India
Prajapati, V.K., Department of Biochemistry, School of Life Sciences, Central University of Rajasthan, NH‑8 Bandarsindri, Ajmer, Rajasthan 305817, India
Poluri, K.M., Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand 247667, India
Mishra, A., Cellular and Molecular Neurobiology Unit, Indian Institute of Technology, Jodhpur, Rajasthan 342037, India
Funding Details: The work was supported by the Science & Engineering Research Board (SERB), Department of Science & Technology, Government of India grant to (AM) EMR/2016/000716 and from BRNS grant to (AM) 54/14/16/2020-BRNS-Government of India.. 54/14/16/2020-BRNS-Government, EMR/2016/000716; Science and Engineering Research Board, SERB
Corresponding Author: Mishra, A.; Cellular and Molecular Neurobiology Unit, India; email:
Appears in Collections:Journal Publications [BT]

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