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Title: Hydrothermal synthesis of gelatin quantum dots for high-performance biological imaging applications
Authors: Paul S.
Banerjee S.L.
Khamrai M.
Samanta S.
Singh S.
Kundu, Patit Paban
Ghosh A.K.
Published in: Journal of Photochemistry and Photobiology B: Biology
Abstract: In the present study, we are reporting a one-pot synthesis of gelatin quantum dots (GeQDs) by the hydrothermal process. The synthesized GeQDs were characterized by fourier transform infrared spectroscopy, nuclear magnetic resonance, ultraviolet-visible and photoluminescence spectroscopic techniques, and also by using high-resolution transmission electron microscopy. The GeQDs showed a high level of photoluminescence quantum yield (PLQY) with significantly higher stability for up to 6 months and presented similar fluorescent intensity as the initial PLQY without any precipitation and aggregation at ambient condition. The cell imaging ability of synthesized GeQDs was examined using cells belonging to diverse clinical backgrounds like bacterial cells including Escherichia coli and Staphylococcus aureus, yeast cells including Candida albicans, C. krusei, C. parapsilosis, and C. tropicalis, mycelial fungi including Aspergillus flavus and A. fumigatus cells, cancer cell lines A549, HEK293 and L929. The results demonstrated that the GeQDs illuminates the cells and can be utilized as potential cell labeling non-toxic biomarkers. In conclusion, it can be said that the gelatin stabilized QDs are a promising candidate for stable and long-term fluorescent imaging of different types of cells.
Citation: Journal of Photochemistry and Photobiology B: Biology(2020), 212(): -
Issue Date: 2020
Publisher: Elsevier B.V.
Keywords: Cell imaging
Quantum dots
ISSN: 10111344
Author Scopus IDs: 56464610400
Author Affiliations: Paul, S., Department of medical microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Banerjee, S.L., Advanced Polymer Laboratory, Department of Polymer Science & Technology, 92 A. P. C. Road, University of Calcutta,
Funding Details: We express our gratitude to the Department of Medical Microbiology, PGIMER, Chandigarh and Department of Polymer Science & Technology, University of Calcutta for allowing us to conduct this study. Saikat Paul designed the study, conducted the experiments,
Corresponding Author: Ghosh, A.K.India; email:
Appears in Collections:Journal Publications [CH]

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