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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/18595
Title: Fabricating scaffolds by microfluidics
Authors: Chung K.-Y.
Mishra, Narayan Chandra
Wang C.-C.
Lin F.-H.
Lin K.-H.
Published in: Proceedings of Biomicrofluidics
Abstract: In this paper, we demonstrate for the first time the technique to using microfluidics to fabricate tissue engineering scaffolds with uniform pore sizes. We investigate both the bubble generation of the microfluidic device and the application of foam as a tissue engineering scaffold. Our microfluidic device consists of two concentric tapered channels, which are made by micropipettes. Nitrogen gas and aqueous alginate solution with Pluronic® F127 surfactant are pumped through the inner and the outer channels, respectively. We observe rich dynamic patterns of bubbles encapsulated in the liquid droplets. The size of the bubble depends linearly on the gas pressure and inversely on the liquid flow rate. In addition, monodisperse bubbles self-assemble into crystalline structures. The liquid crystalline foams are further processed into open-cell solid foams. The novel foam gel was used as a scaffold to culture chondrocytes. © 2009 American Institute of Physics.
Citation: Proceedings of Biomicrofluidics, (2009)
URI: https://doi.org/10.1063/1.3122665
http://repository.iitr.ac.in/handle/123456789/18595
Issue Date: 2009
Publisher: American Institute of Physics Inc.
ISSN: 19321058
Author Scopus IDs: 27267472200
36798999600
41762857900
26643553600
16042634200
Author Affiliations: Chung, K.-Y., Institute of Physics, Academia Sinica, Taipei 115, Taiwan
Mishra, N.C., Department of Paper Technology, Indian Institute of Technology, Roorkee, Saharanpur 247 001, India
Wang, C.-C., Tzu Chi General Hospital, Taipei, Taiwan, Institute of Biomedical Engineering, National Taiwan University, Taipei 100, Taiwan
Lin, F.-H., Institute of Biomedical Engineering, National Taiwan University, Taipei 100, Taiwan
Lin, K.-H., Institute of Physics and Research Center for Applied Science, Academia Sinica, Taipei 115, Taiwan
Corresponding Author: Lin, K.H.; Institute of Physics and Research Center for Applied Science, Academia Sinica, Taipei 115, Taiwan; email: khlin@phys.sinica.edu.tw
Appears in Collections:Conference Publications [PE]

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