Skip navigation
Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/18282
Title: Drug loading in pulp cellulose fiber and its release behavior
Authors: Rastogi V.K.
Dattatreya J.G.
Chattopadhyay S.
Ray A.K.
Published in: Proceedings of AIChE Annual Meeting, Conference Proceedings
Abstract: In this present investigation, we are proposing cellulosic fibers (natural origin), to be used as drug carrier. Among the drug molecules sodium bicarbonate (an antacid) and paracetamol (a neutral anti-inflammatory) were selected to load into the cellulose fibers. Drug loading was carried out in cellulosic fibers by standard technique. Drug loaded fibers were properly washed to remove any surface adhered drug molecule. Then these drug loaded fibers were dipped into release medium with a constant stirring at three different temperatures i.e. 30°C, 35°C, and 40°C. Drug released from the fibers into phosphate buffered saline at above mentioned temperatures were estimated at various time intervals by measuring the absorption maxima of the drug by using the UV- spectrophotometer. From these measurements and the use of a mathematical model, we were able to determine the diffusion coefficients for sodium bicarbonate and paracetamol at various temperatures and finally activation energy values (12.8 kJ/mol for NaHCO3, and 19.8 kJ/mol for paracetamol) were determined .Therefore, this extensive investigation was undertaken to examine the hypothesis whether the cellulosic fibers (natural) can be used as a effective drug carrier. In order to fulfil the aim a suitable mathematical model was used based on the geometry of the drug carrier and appropriate initial and boundary conditions.
Citation: Proceedings of AIChE Annual Meeting, Conference Proceedings, (2012). Pittsburgh, PA
URI: http://repository.iitr.ac.in/handle/123456789/18282
Issue Date: 2012
Keywords: Absorption maxima
Anti-inflammatories
Cellulose fiber
Cellulosic fibers
Drug carrier
Drug loading
Drug molecules
Drug-loaded fibers
Paracetamol
Phosphate-buffered salines
Release behaviors
Sodium bicarbonates
Time interval
Activation energy
Carbonates
Diffusion
Mathematical models
Molecules
Textile fibers
Loading
ISBN: 9780816910731
Author Scopus IDs: 7006364661
55541717000
7403001849
34768855100
Author Affiliations: Rastogi, V.K., Department of Paper Technology, IIT Roorkee, Saharanpur 247 001, India
Dattatreya, J.G., Department of Paper Technology, IIT Roorkee, Saharanpur 247 001, India
Chattopadhyay, S., Department of Paper Technology, IIT Roorkee, Saharanpur 247 001, India
Ray, A.K., Department of Paper Technology, IIT Roorkee, Saharanpur 247 001, India
Corresponding Author: Rastogi, V.K.; Department of Paper Technology, IIT Roorkee, Saharanpur 247 001, India
Appears in Collections:Conference Publications [PH]

Files in This Item:
There are no files associated with this item.
Show full item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.