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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/1693
Title: Microwave-assisted synthesis of N-substituted cyclic imides and their evaluation for anticancer and anti-inflammatory activities
Authors: Sondhi S.M.
Rani R.
Roy, Partha
Agrawal S.K.
Saxena A.K.
Published in: Bioorganic and Medicinal Chemistry Letters
Abstract: A number of N-substituted cyclic imides 3a-e, 5a-e, 7a-d, and 9a-e have been synthesized in very high yields, by condensation of various diacids 2, 4, 6, and 8 with different amines under microwave irradiation. These compounds were screened for anticancer and anti-inflammatory activities, and compounds 3c, 3e, 5c, 9c, and 9d exhibited anticancer activity against colon (COLO 205) cancer better than 5-fluorouracil and mitomycin-C, and compound 9b exhibited anti-inflammatory activity better than standard drug phenyl butazone. © 2009.
Citation: Bioorganic and Medicinal Chemistry Letters (2009), 19(5): 1534-1538
URI: https://doi.org/10.1016/j.bmcl.2008.07.048
http://repository.iitr.ac.in/handle/123456789/1693
Issue Date: 2009
Keywords: Anti-inflammatory
Anticancer
Cyclicimide
Microwave
ISSN: 0960894X
Author Scopus IDs: 7006090710
16507511200
35509207200
24173353300
7401482447
Author Affiliations: Sondhi, S.M., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, Uttaranchal 247667, India
Rani, R., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, Uttaranchal 247667, India
Roy, P., Department of Biotechnology, Indian Institute of Technology-Roorkee, Roorkee, Uttaranchal 247667, India
Agrawal, S.K., Indian Institute of Integrative Medicine, Pharmacology Division, Jammu, 180001, India
Saxena, A.K., Indian Institute of Integrative Medicine, Pharmacology Division, Jammu, 180001, India
Funding Details: We are thankful to technical staff of the Chemistry Department, I.I.T. Roorkee, for spectroscopic studies and elemental analysis. Thanks also due to Head I.I.C. for providing NMR facility. Ms. Reshma Rani (SRF) and Mr. Satyam Kumar Agrawal (SRF) are thankful to CSIR, New Delhi, for financial assistance.
Corresponding Author: Sondhi, S.M.; Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, Uttaranchal 247667, India; email: sondhifcy@iitr.ernet.in
Appears in Collections:Journal Publications [BT]

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