http://repository.iitr.ac.in/handle/123456789/1693| Title: | Microwave-assisted synthesis of N-substituted cyclic imides and their evaluation for anticancer and anti-inflammatory activities |
| Authors: | Sondhi S.M. Rani R. Roy, Partha Agrawal S.K. Saxena A.K. |
| Published in: | Bioorganic and Medicinal Chemistry Letters |
| Abstract: | A number of N-substituted cyclic imides 3a-e, 5a-e, 7a-d, and 9a-e have been synthesized in very high yields, by condensation of various diacids 2, 4, 6, and 8 with different amines under microwave irradiation. These compounds were screened for anticancer and anti-inflammatory activities, and compounds 3c, 3e, 5c, 9c, and 9d exhibited anticancer activity against colon (COLO 205) cancer better than 5-fluorouracil and mitomycin-C, and compound 9b exhibited anti-inflammatory activity better than standard drug phenyl butazone. © 2009. |
| Citation: | Bioorganic and Medicinal Chemistry Letters (2009), 19(5): 1534-1538 |
| URI: | https://doi.org/10.1016/j.bmcl.2008.07.048 http://repository.iitr.ac.in/handle/123456789/1693 |
| Issue Date: | 2009 |
| Keywords: | Anti-inflammatory Anticancer Cyclicimide Microwave |
| ISSN: | 0960894X |
| Author Scopus IDs: | 7006090710 16507511200 35509207200 24173353300 7401482447 |
| Author Affiliations: | Sondhi, S.M., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, Uttaranchal 247667, India Rani, R., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, Uttaranchal 247667, India Roy, P., Department of Biotechnology, Indian Institute of Technology-Roorkee, Roorkee, Uttaranchal 247667, India Agrawal, S.K., Indian Institute of Integrative Medicine, Pharmacology Division, Jammu, 180001, India Saxena, A.K., Indian Institute of Integrative Medicine, Pharmacology Division, Jammu, 180001, India |
| Funding Details: | We are thankful to technical staff of the Chemistry Department, I.I.T. Roorkee, for spectroscopic studies and elemental analysis. Thanks also due to Head I.I.C. for providing NMR facility. Ms. Reshma Rani (SRF) and Mr. Satyam Kumar Agrawal (SRF) are thankful to CSIR, New Delhi, for financial assistance. |
| Corresponding Author: | Sondhi, S.M.; Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, Uttaranchal 247667, India; email: sondhifcy@iitr.ernet.in |
| Appears in Collections: | Journal Publications [BT] |
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