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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/1676
Title: Solvent free synthesis, anti-inflammatory and anticancer activity evaluation of tricyclic and tetracyclic benzimidazole derivatives
Authors: Sondhi S.M.
Rani R.
Singh J.
Roy, Partha
Agrawal S.K.
Saxena A.K.
Published in: Bioorganic and Medicinal Chemistry Letters
Abstract: Heterocyclic benzimidazole derivatives 3a-h, 5a-c and 7a-d have been synthesized by condensation of succinic acid (1) homophthalic acid (4) and 2,3-pyrazinedicarboxlic acid (6) with various substituted diamines under microwave irradiation in good yields. Structures assigned to 3a-h, 5a-c and 7a-d are fully supported by spectral data. All these compounds were screened for anti-inflammatory and anticancer activities. At a dose of 50 mg/kg po compounds 3b (39.4%) and 3c (39.2%) exhibited anti-inflammatory activity, comparable to standard ibuprofen which showed 39% activity at 50 mg/kg po and compound 7c exhibit good anticancer activity against ovary (IGR-OV-1), breast (MCF-7) and CNS(SF-295) human cancer cell lines. © 2010 Elsevier Ltd. All rights reserved.
Citation: Bioorganic and Medicinal Chemistry Letters (2010), 20(7): 2306-2310
URI: https://doi.org/10.1016/j.bmcl.2010.01.147
http://repository.iitr.ac.in/handle/123456789/1676
Issue Date: 2010
Keywords: Anti-inflammatory
Anticancer
Benzimidazole
Heterocyclic
Microwave
ISSN: 0960894X
Author Scopus IDs: 7006090710
16507511200
55330178200
35509207200
24173353300
7401482447
Author Affiliations: Sondhi, S.M., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee 247 667 UK, India
Rani, R., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee 247 667 UK, India
Singh, J., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee 247 667 UK, India
Roy, P., Department of Biotechnology, Indian Institute of Technology-Roorkee, Roorkee 247 667 UK, India
Agrawal, S.K., Indian Institute of Integrative Medicine, Pharmacology Division, Jammu, 180 001, India
Saxena, A.K., Indian Institute of Integrative Medicine, Pharmacology Division, Jammu, 180 001, India
Funding Details: We are thankful to technical staff of the Chemistry Department, I. I. T. Roorkee, for spectroscopic studies and elemental analysis. One of the authors Ms. Reshma Rani (SRF-NET) is thankful to CSIR , New Delhi, for financial assistance.
Corresponding Author: Sondhi, S.M.; Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee 247 667 UK, India; email: sondifcy@iitr.ernet.in
Appears in Collections:Journal Publications [BT]

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