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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/1672
Title: Conventional and microwave assisted synthesis of small molecule based biologically active heterocyclic amidine derivatives
Authors: Sondhi S.M.
Rani R.
Roy, Partha
Agrawal S.K.
Saxena A.K.
Published in: European Journal of Medicinal Chemistry
Abstract: Heterocyclic amidine derivatives have been synthesized by condensation of 2-cyanopyrazine, 4-cyanopyridine and 2-cyanopyridine with furfurylamine, histamine, 1-(3-aminopropyl)imidazole, 4-picolylamine, 2-picolylamine, and tryptamine respectively, in the presence of sodium methoxide as well as via microwave irradiation in good yields. All these compounds were screened for anti-inflammatory and anticancer activities. At a dose of 50 mg/kg p.o. compounds 3a (36.6%), 3d (32%), 4d (31.0%) and 4e (33.8%) exhibited good anti-inflammatory activity, comparable to standard drug ibuprofen which showed 39% activity at 50 mg/kg p.o. © 2009 Elsevier Masson SAS. All rights reserved.
Citation: European Journal of Medicinal Chemistry (2010), 45(3): 902-908
URI: https://doi.org/10.1016/j.ejmech.2009.11.030
http://repository.iitr.ac.in/handle/123456789/1672
Issue Date: 2010
Keywords: Amidine
Anti cancer
Anti-inflammatory
Heterocyclic
Microwave
ISSN: 2235234
Author Scopus IDs: 7006090710
16507511200
35509207200
24173353300
7401482447
Author Affiliations: Sondhi, S.M., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee 247667, uttaranchal, India
Rani, R., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee 247667, uttaranchal, India
Roy, P., Department of Biotechnology, Indian Institute of Technology-Roorkee, Roorkee 247667, uttaranchal, India
Agrawal, S.K., Indian Institute of Integrative Medicine, Pharmacology Division, Jammu, 180001, India
Saxena, A.K., Indian Institute of Integrative Medicine, Pharmacology Division, Jammu, 180001, India
Funding Details: We are thankful to technical staff of the Chemistry Department, I. I. T. Roorkee, for spectroscopic studies and elemental analysis. Thanks also due to Head I.I.C. for providing NMR facility. Ms. Reshma Rani (SRF) is thankful to CSIR, New Delhi, for financial assistance
Corresponding Author: Sondhi, S.M.; Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee 247667, uttaranchal, India; email: sondifcy@iitr.ernet.in
Appears in Collections:Journal Publications [BT]

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