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dc.contributor.authorSondhi S.M.-
dc.contributor.authorSingh J.-
dc.contributor.authorRoy, Partha-
dc.contributor.authorAgrawal S.K.-
dc.contributor.authorSaxena A.K.-
dc.date.accessioned2020-09-30T11:39:35Z-
dc.date.available2020-09-30T11:39:35Z-
dc.date.issued2011-
dc.identifier.citationMedicinal Chemistry Research (2011), 20(7): 887-897-
dc.identifier.issn10542523-
dc.identifier.urihttps://doi.org/10.1007/s00044-010-9410-6-
dc.identifier.urihttp://repository.iitr.ac.in/handle/123456789/1652-
dc.description.abstractA number of imidazole derivatives 3a-f and 4a-f have been synthesized by the condensation of 3-methylthiophen-2-carboxaldehyde 1a, 5-methylthiophen- 2-carboxaldehyde 1b, N-methylpyrrol-2-carboxaldehyde 1c, 1-naphthaldehyde 1d, 2-naphthaldehyde 1e, and 2-hydroxy-1-naphthaldehyde 1f with 1,2- diaminoanthraquinone 2a and 2,3-diaminophenazine 2b, respectively. Condensation of 2-guanidinobenzimidazole with functionalized aldehydes 1a-f leads to the formation of guanidine derivatives 5a-f. Both imidazole (3a-f, 4a-f) and guanidine derivatives (5a-f) were synthesized in good yields using conventional heating and microwave irradiation techniques. Structures assigned to compounds 3a-f, 4a-f and 5a-f are supported by correct spectral and analytic data. On screening for anti-inflammatory and anticancer activities, compounds 3e, 4a and 5a exhibited good anti-inflammatory and compounds 3d, 3f, 4d and 4f showed very good anticancer activity. © Springer Science+Business Media, LLC 2010.-
dc.language.isoen_US-
dc.relation.ispartofMedicinal Chemistry Research-
dc.subjectAnti-inflammatory-
dc.subjectAnticancer-
dc.subjectGuanidine-
dc.subjectImidazole-
dc.subjectMicrowave irradiation-
dc.titleConventional and microwave-assisted synthesis of imidazole and guanidine derivatives and their biological evaluation-
dc.typeArticle-
dc.scopusid7006090710-
dc.scopusid55330178200-
dc.scopusid35509207200-
dc.scopusid24173353300-
dc.scopusid7401482447-
dc.affiliationSondhi, S.M., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee 247667, UK, India-
dc.affiliationSingh, J., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee 247667, UK, India-
dc.affiliationRoy, P., Department of Biotechnology, Indian Instituteof Technology-Roorkee, Roorkee 247667, UK, India-
dc.affiliationAgrawal, S.K., Pharmacology Division, Indian Institute of Integrative Medicine, Jammu 180001, India-
dc.affiliationSaxena, A.K., Pharmacology Division, Indian Institute of Integrative Medicine, Jammu 180001, India-
dc.description.fundingAcknowledgements We thank the technical staff of the Chemistry Department, IIT. Roorkee, for their assistance in spectroscopic studies and elemental analysis. One of the authors—Mr. Jaiveer Singh (SRF-NET)—thanks the CSIR, New Delhi, for financial assistance.-
dc.description.correspondingauthorSondhi, S.M.; Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee 247667, UK, India; email: sondifcy@iitr.ernet.in-
Appears in Collections:Journal Publications [BT]

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