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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/1652
Title: Conventional and microwave-assisted synthesis of imidazole and guanidine derivatives and their biological evaluation
Authors: Sondhi S.M.
Singh J.
Roy, Partha
Agrawal S.K.
Saxena A.K.
Published in: Medicinal Chemistry Research
Abstract: A number of imidazole derivatives 3a-f and 4a-f have been synthesized by the condensation of 3-methylthiophen-2-carboxaldehyde 1a, 5-methylthiophen- 2-carboxaldehyde 1b, N-methylpyrrol-2-carboxaldehyde 1c, 1-naphthaldehyde 1d, 2-naphthaldehyde 1e, and 2-hydroxy-1-naphthaldehyde 1f with 1,2- diaminoanthraquinone 2a and 2,3-diaminophenazine 2b, respectively. Condensation of 2-guanidinobenzimidazole with functionalized aldehydes 1a-f leads to the formation of guanidine derivatives 5a-f. Both imidazole (3a-f, 4a-f) and guanidine derivatives (5a-f) were synthesized in good yields using conventional heating and microwave irradiation techniques. Structures assigned to compounds 3a-f, 4a-f and 5a-f are supported by correct spectral and analytic data. On screening for anti-inflammatory and anticancer activities, compounds 3e, 4a and 5a exhibited good anti-inflammatory and compounds 3d, 3f, 4d and 4f showed very good anticancer activity. © Springer Science+Business Media, LLC 2010.
Citation: Medicinal Chemistry Research (2011), 20(7): 887-897
URI: https://doi.org/10.1007/s00044-010-9410-6
http://repository.iitr.ac.in/handle/123456789/1652
Issue Date: 2011
Keywords: Anti-inflammatory
Anticancer
Guanidine
Imidazole
Microwave irradiation
ISSN: 10542523
Author Scopus IDs: 7006090710
55330178200
35509207200
24173353300
7401482447
Author Affiliations: Sondhi, S.M., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee 247667, UK, India
Singh, J., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee 247667, UK, India
Roy, P., Department of Biotechnology, Indian Instituteof Technology-Roorkee, Roorkee 247667, UK, India
Agrawal, S.K., Pharmacology Division, Indian Institute of Integrative Medicine, Jammu 180001, India
Saxena, A.K., Pharmacology Division, Indian Institute of Integrative Medicine, Jammu 180001, India
Funding Details: Acknowledgements We thank the technical staff of the Chemistry Department, IIT. Roorkee, for their assistance in spectroscopic studies and elemental analysis. One of the authors—Mr. Jaiveer Singh (SRF-NET)—thanks the CSIR, New Delhi, for financial assistance.
Corresponding Author: Sondhi, S.M.; Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee 247667, UK, India; email: sondifcy@iitr.ernet.in
Appears in Collections:Journal Publications [BT]

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