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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/1631
Title: Crimean-congo hemorrhagic fever virus: Strategies to combat with an emerging threat to human
Authors: Pratap S.
Narwal M.
Dev A.
Dhindwal S.
Tomar S.
Kumar P.
Published in: Current Bioinformatics
Abstract: Bunyaviridae family consists of vector borne lethal viruses, stands out as the largest virus family with its 350 members. One such virus of this family, Crimean-Congo hemorrhagic fever virus (CCHFV) is transmitted through bites of ixodid ticks or by direct contact with blood from infected animals. Crimean-Congo haemorrhagic fever (CCHF) is a severe disease in humans which is endemic in large parts of the world with a high mortality rate. This virus could also be used as a bioterrorism agent due to its human-to-human transmission with no specific therapy. The pathogenicity factor of CCHFV is unexplored due to the lack of animal models. CCHFV, being an RNA virus, is able to mutate rapidly hence preventing the development of effective therapy against it. Till now ribavarin is the only available drug for supportive treatment but has many side-effects. New technologies like RNA interference have emerged as a solution for epidemics of CCHF. RNAi is a sequence specific approach, has been used successfully against different pathogens. This review focuses on designing and application of RNAi with emphasis on the role of bioinformatics for the anti CCHFV therapeutic development strategy. © 2012 Bentham Science Publishers.
Citation: Current Bioinformatics(2012), 7(4): 467-477
URI: https://doi.org/10.2174/157489312803900901
http://repository.iitr.ac.in/handle/123456789/1631
Issue Date: 2012
Publisher: Bentham Science Publishers B.V.
Keywords: Bunyaviridae
CCHFV
Crimean-congo hemorrhagic fever
Nairoviridae
RNAi
SiRNA
ISSN: 15748936
Author Scopus IDs: 54412938100
49461618600
55620085000
36082537700
57203506001
55064809000
Author Affiliations: Pratap, S., Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee-247667, Uttarakhand, India
Narwal, M., Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee-247667, Uttarakhand, India
Dev, A., Department
Corresponding Author: Pratap, S.; Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee-247667, Uttarakhand, India
Appears in Collections:Journal Publications [BT]

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