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dc.contributor.authorSondhi S.M.-
dc.contributor.authorSingh J.-
dc.contributor.authorAgrawal S.K.-
dc.contributor.authorSaxena A.K.-
dc.contributor.authorRoy, Partha-
dc.date.accessioned2020-09-30T11:39:29Z-
dc.date.available2020-09-30T11:39:29Z-
dc.date.issued2012-
dc.identifier.citationMedicinal Chemistry Research (2012), 21(1): 91-99-
dc.identifier.issn10542523-
dc.identifier.urihttps://doi.org/10.1007/s00044-010-9507-y-
dc.identifier.urihttp://repository.iitr.ac.in/handle/123456789/1620-
dc.description.abstractCondensation of various amines (Ia-c) with 4-isothiocyanato-4-methyl-2- pentanone (2a) at room temperature gave tetrahydropyrimidinethiones (3a-c) whereas condensation of 1a-e with 3-isothiocyanatobutanal at room temperature gave tetrahydropyrimidinethiones (4a-e). Amines 1a, d, f-i on condensation with 4-isothiocyanato-4- methyl-2-pentanone (2a) by heating under reflux for 8 h at pH ? 4 (for 1a, d) and at RT (for 1f-i) gave dihydropyrimidinethiones 5a-b and 5c-f, respectively. Condensation of 1f with 3-isothiocyanatobutanal gave dihydropyimidinethione 6. When isothiocyanate (2a) and phenylenediamine derivatives 1g, h were heated under reflux at pH ?4, tricyclic compounds 7a, b were obtained in good yields. Condensation of 3-isothiocyanatobutanal with o-phenylenediamines 1h and 1j at pH ? 5 by refluxing in methanol for 8 h gave products 8 and 9. All these compounds were screened for anti-inflammatory activity. Compounds 3c, 4c and 7a exhibited anti-inflammatory activity comparable to standard drug ibuprofen. © Springer Science+Business Media, LLC 2010.-
dc.language.isoen_US-
dc.relation.ispartofMedicinal Chemistry Research-
dc.subjectAnti-inflammatory activity-
dc.subjectCondensed pyrimidine-
dc.subjectHeterocyclic compounds-
dc.subjectPyrimidine-
dc.titleSynthesis of pyrimidine and condensed pyrimidine derivatives and their evaluation for anti-inflammatory activity-
dc.typeArticle-
dc.scopusid7006090710-
dc.scopusid55330178200-
dc.scopusid24173353300-
dc.scopusid7401482447-
dc.scopusid35509207200-
dc.affiliationSondhi, S.M., Department of Chemistry, Indian Institute of Technology, Roorkee 247667, Uttarakhand, India-
dc.affiliationSingh, J., Department of Chemistry, Indian Institute of Technology, Roorkee 247667, Uttarakhand, India-
dc.affiliationAgrawal, S.K., Pharmacology Division, Indian Institute of Integrative Medicine, Jammu 180001, India-
dc.affiliationSaxena, A.K., Pharmacology Division, Indian Institute of Integrative Medicine, Jammu 180001, India-
dc.affiliationRoy, P., Department of Biotechnology, Indian Institute of Technology, Roorkee 247667, Uttarakhand, India-
dc.description.fundingAcknowledgments We are thankful to technical staff of the Chemistry Department, I. I. T. Roorkee, for spectroscopic studies and elemental analysis. One of the authors Mr. Jaiveer Singh (SRF-NET) is thankful to CSIR, New Delhi, for financial assistance.-
dc.description.correspondingauthorSondhi, S.M.; Department of Chemistry, Indian Institute of Technology, Roorkee 247667, Uttarakhand, India; email: sondifcy@iitr.ernet.in-
Appears in Collections:Journal Publications [BT]

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