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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/1619
Title: Synthesis anti-inflammatory and anticancer activity evaluation of some pyrazole and oxadiazole derivatives
Authors: Sondhi S.M.
Kumar S.
Kumar N.
Roy P.
Published in: Medicinal Chemistry Research
Abstract: Pyrazole derivatives IIa-l have been synthesized by condensation of chalcones Ia-f with hydrazine hydrate and phenyl hydrazine under microwave irradiation in good yields. Oxadiazole derivatives IVa-f have been synthesized by condensation of N'-hydroxypicolinamidine, N'-hydroxy isonicotinamidine, N'-hydroxypyrazine- 2-carboxamidine with 2,5 dimethoxybenzaldehyde and 3-methoxy-4-hydroxy benzaldehyde, respectively. Structures assigned to IIa-l and IVa-f are fully supported by correct spectral and analytical data. All compounds (IIa-l & IVa-f) have been screened for anti-inflammatory and anticancer activities. Compounds IIj, IIk, and IVb exhibited good anti-inflammatory activity, while, IIa, c, j, and IVd showed better anticancer activity against four and three cancer cell lines, respectively. © Springer Science+Business Media, LLC 2011.
Citation: Medicinal Chemistry Research (2012), 21(10): 3043-3052
URI: https://doi.org/10.1007/s00044-011-9850-7
http://repository.iitr.ac.in/handle/123456789/1619
Issue Date: 2012
Keywords: Anti-inflammatory activity
Anticancer
Oxadiazole derivatives
Pyrazole derivatives
ISSN: 10542523
Author Scopus IDs: 7006090710
57216459762
57192281884
35509207200
Author Affiliations: Sondhi, S.M., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee 247667, UK, India
Kumar, S., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee 247667, UK, India
Kumar, N., Department of Biotechnology, Indian Institute of Technology-Roorkee, Roorkee 247667, UK, India
Roy, P., Department of Biotechnology, Indian Institute of Technology-Roorkee, Roorkee 247667, UK, India
Funding Details: Acknowledgments We are thankful to technical staff of the Chemistry Department, I. I. T. Roorkee, for spectroscopic studies and elemental analysis and to Mr Rakesh Kumar (Integral Biosciences Ltd, Noida) for helping to use microwave reactor. Mr. Sandeep Kumar is thankful to MHRD New Delhi for financial assistance.
Corresponding Author: Sondhi, S.M.; Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee 247667, UK, India; email: sondifcy@iitr.ernet.in
Appears in Collections:Journal Publications [BT]

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