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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/1589
Title: Synthesis, anti-inflammatory, and cytotoxicity evaluation of 9,10-dihydroanthracene-9,10-?,?-succinimide and bis-succinimide derivatives
Authors: Arya S.
Kumar S.
Rani R.
Kumar N.
Roy P.
Sondhi S.M.
Published in: Medicinal Chemistry Research
Abstract: 9,10-Dihydroanthracene-9,10-?,?-succinimide derivatives 4a-e and bis-succinimide derivatives 6a-e have been synthesized by grinding 9,10-dihydroanthracene-9,10-?,?-succinic anhydride 2 with various mono 3a-e and diamines 5a-e in quantitative yields. All the target compounds were fully characterized by spectrometric and spectroscopic means. Compounds 4a-e, 6a-e and recently reported compounds 4f-p were screened for anti-inflammatory and for cytotoxicity against five human cancer cell lines: T47D, NCI H-522, HCT-15, PA1, and HepG-2. Compounds 4e, 4i, 4j, and 4p exhibited good anti-inflammatory activity and compounds with interesting cytotoxic profile were 4c, 6e (T47D); 4e, 4o (NCI H-522); 4n (HCT-15); 4e, 4h, 4o (PA1); and 4a, 4e, 4f, 4i, 4o (HepG-2). © 2013 Springer Science+Business Media New York.
Citation: Medicinal Chemistry Research (2013), 22(9): 4278-4285
URI: https://doi.org/10.1007/s00044-012-0439-6
http://repository.iitr.ac.in/handle/123456789/1589
Issue Date: 2013
Keywords: Anti-inflammatory
Cytotoxicity
Green method
Succinimide derivatives
ISSN: 10542523
Author Scopus IDs: 54402273600
57216459762
16507511200
57192281884
35509207200
7006090710
Author Affiliations: Arya, S., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee 247667 Uttarakhand, India
Kumar, S., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee 247667 Uttarakhand, India
Rani, R., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee 247667 Uttarakhand, India
Kumar, N., Department of Biotechnology, Indian Institute of Technology-Roorkee, Roorkee 247667 Uttarakhand, India
Roy, P., Department of Biotechnology, Indian Institute of Technology-Roorkee, Roorkee 247667 Uttarakhand, India
Sondhi, S.M., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee 247667 Uttarakhand, India
Funding Details: Acknowledgments We are thankful to technical staff of the Chemistry Department, I. I. T. Roorkee, for spectroscopic studies and elemental analysis. Thanks also due to Head I. I. C. for providing NMR facility. We are thankful to Prof. G. Bhattacharjee and Prof. Ravi Bhushan of the Chemistry Department, I. I. T. Roorkee for helpful discussion. Ms. Surbhi Arya (SRF) and Reshma Rani are thankful to CSIR, New Delhi, and Mr. Sandeep Kumar to MHRD, New Delhi for financial assistance.
Corresponding Author: Sondhi, S.M.; Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee 247667 Uttarakhand, India; email: sondifcy@iitr.ernet.in
Appears in Collections:Journal Publications [BT]

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