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dc.contributor.authorKumar S.-
dc.contributor.authorKumar N.-
dc.contributor.authorRoy, Partha-
dc.contributor.authorSondhi S.M.-
dc.date.accessioned2020-09-30T11:39:24Z-
dc.date.available2020-09-30T11:39:24Z-
dc.date.issued2013-
dc.identifier.citationMedicinal Chemistry Research (2013), 22(10): 4600-4609-
dc.identifier.issn10542523-
dc.identifier.urihttps://doi.org/10.1007/s00044-012-0438-7-
dc.identifier.urihttp://repository.iitr.ac.in/handle/123456789/1585-
dc.description.abstractCondensation of iminodiacetic acid 1 with various amines i.e., cyclohexanamine, 1-(3-aminopropyl)imidazole, pyridin-2-ylmethanamine, pyridin-3-ylmethanamine, pyridin-4-ylmethanamine, 2-morpholinoethanamine, thiophen-2-ylmethanamine, 2-(thiophen-2-yl)ethanamine, furan-2-ylmethanamine, 2-(pyrrolidin-1-yl)ethanamine, and 1-(3-aminopropyl) pyrrolidin-2-one 2a-k under microwave irradiation gave the corresponding piperazine-2,6-dione derivatives 3a-k in quantitative yields. Piperazine-2,6-dione derivatives 3a-k on condensation with 1H-indole-2-carboxylic acid under microwave irradiation gave the corresponding 4-(1H-indole-2-carbonyl)piperazine-2,6-dione derivatives 4a-k in quantitative yields. All the synthesized compounds (3a-k & 4a-k) were purified by crystallization and characterized by spectroscopic means. On screening at a concentration of 10 ?M, compounds 3k, 4e, 4i breast (T47D), 4j lung (NCI H-522), 3i colon (HCT-15), 4e ovary (PA-1), and 4g liver (HepG-2) exhibited good anticancer activity. © 2013 Springer Science+Business Media New York.-
dc.language.isoen_US-
dc.relation.ispartofMedicinal Chemistry Research-
dc.subjectAnticancer activity-
dc.subjectMicrowave synthesis-
dc.subjectPiperazine dione derivatives-
dc.titleEfficient synthesis of piperazine-2,6-dione and 4-(1H-indole-2-carbonyl) piperazine-2,6-dione derivatives and their evaluation for anticancer activity-
dc.typeArticle-
dc.scopusid57216459762-
dc.scopusid57192281884-
dc.scopusid35509207200-
dc.scopusid7006090710-
dc.affiliationKumar, S., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee 247667 Uttrakhand, India-
dc.affiliationKumar, N., Department of Biotechnology, Indian Institute of Technology-Roorkee, Roorkee 247667 Uttrakhand, India-
dc.affiliationRoy, P., Department of Biotechnology, Indian Institute of Technology-Roorkee, Roorkee 247667 Uttrakhand, India-
dc.affiliationSondhi, S.M., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee 247667 Uttrakhand, India-
dc.description.fundingAcknowledgments We are thankful to the technical staff of the Chemistry Department, I. I. T. Roorkee, for spectroscopic studies and elemental analysis and also to Head I. I. C. for providing NMR facility. Special thanks are due to Prof. G. Bhattacharjee and Prof. Ravi Bhushan of Chemistry Department, I. I. T. Roorkee, for helpful discussion. Mr. Sandeep Kumar is thankful to MHRD, New Delhi for financial assistance.-
dc.description.correspondingauthorSondhi, S.M.; Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee 247667 Uttrakhand, India; email: sondifcy@iitr.ernet.in-
Appears in Collections:Journal Publications [BT]

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