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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/1579
Title: Synthesis of amidine and bis amidine derivatives and their evaluation for anti-inflammatory and anticancer activity
Authors: Arya S.
Kumar N.
Roy P.
Sondhi S.M.
Published in: European Journal of Medicinal Chemistry
Abstract: 2-Cyanopyridine (1a), 4-cyanopyridine (1b), 2-cyanopyrazine (1c) on condensation with mono amines (2a-c) and diamines (4a-c) in the presence of sodium methoxide as catalyst gave amidine derivatives (3a-i) and bis amidine derivatives (5a-i) in good yields. All these compounds were fully characterized by spectroscopic means and elemental analysis. On screening for anti-inflammatory activity and for in vitro anticancer activity compounds 5c and 5d exhibited good anti-inflammatory activity whereas compounds 5d breast (T47D), 5h, 5i lung (NCI H-522), 5i colon (HCT-15), 3c, 3h, 5i ovary (PA-1) and 3c, 5b, 5h liver (HepG2) exhibited good anticancer activity.© 2012 Elsevier Masson SAS. All rights reserved.
Citation: European Journal of Medicinal Chemistry (2013), 59(): 7-14
URI: https://doi.org/10.1016/j.ejmech.2012.10.046
http://repository.iitr.ac.in/handle/123456789/1579
Issue Date: 2013
Keywords: Amidines
Anti-inflammatory
Anticancer
Bis amidines
Synthesis
ISSN: 2235234
Author Scopus IDs: 54402273600
57192281884
35509207200
7006090710
Author Affiliations: Arya, S., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, 247667 UK, India
Kumar, N., Department of Biotechnology, Indian Institute of Technology-Roorkee, Roorkee, 247667 UK, India
Roy, P., Department of Biotechnology, Indian Institute of Technology-Roorkee, Roorkee, 247667 UK, India
Sondhi, S.M., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, 247667 UK, India
Funding Details: We are thankful to technical staff of the Chemistry Department, I.I.T. Roorkee, for spectroscopic studies and elemental analysis. Thanks also due to Head I.I.C. for providing NMR facility. Ms. Surbhi Arya (SRF) is thankful to CSIR New Delhi for financial assistance.
Corresponding Author: Sondhi, S.M.; Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, 247667 UK, India; email: sondifcy@iitr.ernet.in
Appears in Collections:Journal Publications [BT]

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