http://repository.iitr.ac.in/handle/123456789/15348| Title: | Principal component analysis of elements in atherosclerotic human coronary arteries |
| Authors: | Dutta, Raj Kumar Roijers R.B. Mutsaers P.H.A. De Goeij J.J.M. Van Der Vusse G.J. Jaksic M. Radovic I.B. Medunic Z. |
| Published in: | Proceedings of Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms |
| Abstract: | Principal component analysis was applied to identify normal and pathological structures using combinations of levels of phosphorus, sulphur, chlorine, potassium and calcium in early stages of atherosclerotic coronary arteries. An inverse correlation was found between the combination of Ca-P, and that of S-Cl-K. This finding points towards the presence of smaller calcified deposits in an early phase of atherosclerosis in the human coronary artery. A possible location of cholesterol or some other carbon-based materials could also be identified. Further, a histogram method proved to be useful for characterising calcified structures of Ca/P mass ratio lower than that of hydroxyapatite. An empirical formula of (1-n)Ca3(PO4) 2 • nAm(PO4) is suggested to explain composition of these calcified structures. © 2005 Elsevier B.V. All rights reserved. |
| Citation: | Proceedings of Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, (2005), 245- 250 |
| URI: | https://doi.org/10.1016/j.nimb.2005.01.065 http://repository.iitr.ac.in/handle/123456789/15348 |
| Issue Date: | 2005 |
| Keywords: | Atherosclerosis Calcification Element distribution Nuclear microprobe analysis Principal component analysis |
| ISSN: | 0168583X |
| Author Scopus IDs: | 47161194700 12752158900 7003294979 7005529444 7102878246 |
| Author Affiliations: | Dutta, R.K., Cyclotron Laboratory, Department of Applied Physics, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, Netherlands Roijers, R.B., Cyclotron Laboratory, Department of Applied Physics, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, Netherlands Mutsaers, P.H.A., Cyclotron Laboratory, Department of Applied Physics, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, Netherlands De Goeij, J.J.M., Cyclotron Laboratory, Department of Applied Physics, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, Netherlands, Interfaculty Reactor Institute, Delft University of Technology, Mekelweg 15, 2629 JB Delft, Netherlands Van Der Vusse, G.J., Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, P.O. Box 616, 6200 MD, Maastricht, Netherlands |
| Funding Details: | This research work is supported by FOM Netherlands, project number 00PMT13. |
| Corresponding Author: | Mutsaers, P.H.A.; Cyclotron Laboratory, Department of Applied Physics, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, Netherlands; email: p.h.a.mutsaers@tue.nl |
| Appears in Collections: | Conference Publications [CY] |
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