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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/15348
Title: Principal component analysis of elements in atherosclerotic human coronary arteries
Authors: Dutta, Raj Kumar
Roijers R.B.
Mutsaers P.H.A.
De Goeij J.J.M.
Van Der Vusse G.J.
Jaksic M.
Radovic I.B.
Medunic Z.
Published in: Proceedings of Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
Abstract: Principal component analysis was applied to identify normal and pathological structures using combinations of levels of phosphorus, sulphur, chlorine, potassium and calcium in early stages of atherosclerotic coronary arteries. An inverse correlation was found between the combination of Ca-P, and that of S-Cl-K. This finding points towards the presence of smaller calcified deposits in an early phase of atherosclerosis in the human coronary artery. A possible location of cholesterol or some other carbon-based materials could also be identified. Further, a histogram method proved to be useful for characterising calcified structures of Ca/P mass ratio lower than that of hydroxyapatite. An empirical formula of (1-n)Ca3(PO4) 2 • nAm(PO4) is suggested to explain composition of these calcified structures. © 2005 Elsevier B.V. All rights reserved.
Citation: Proceedings of Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, (2005), 245- 250
URI: https://doi.org/10.1016/j.nimb.2005.01.065
http://repository.iitr.ac.in/handle/123456789/15348
Issue Date: 2005
Keywords: Atherosclerosis
Calcification
Element distribution
Nuclear microprobe analysis
Principal component analysis
ISSN: 0168583X
Author Scopus IDs: 47161194700
12752158900
7003294979
7005529444
7102878246
Author Affiliations: Dutta, R.K., Cyclotron Laboratory, Department of Applied Physics, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, Netherlands
Roijers, R.B., Cyclotron Laboratory, Department of Applied Physics, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, Netherlands
Mutsaers, P.H.A., Cyclotron Laboratory, Department of Applied Physics, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, Netherlands
De Goeij, J.J.M., Cyclotron Laboratory, Department of Applied Physics, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, Netherlands, Interfaculty Reactor Institute, Delft University of Technology, Mekelweg 15, 2629 JB Delft, Netherlands
Van Der Vusse, G.J., Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, P.O. Box 616, 6200 MD, Maastricht, Netherlands
Funding Details: This research work is supported by FOM Netherlands, project number 00PMT13.
Corresponding Author: Mutsaers, P.H.A.; Cyclotron Laboratory, Department of Applied Physics, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, Netherlands; email: p.h.a.mutsaers@tue.nl
Appears in Collections:Conference Publications [CY]

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