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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/15313
Title: Calcium/phosphorus ratios in calcium-rich deposits in atherosclerotic human coronary arteries
Authors: Dutta R.K.
Roijers R.B.
Mutsaers P.H.A.
Pauwels P.
De Goeij J.J.M.
Van Der Vusse G.J.
Jaksic M.
Radovic I.B.
Medunic Z.
Published in: Proceedings of Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
Abstract: Human coronary arteries in both early and advanced stages of atherosclerosis were studied for understanding the nature of Ca deposits in terms of their Ca/P mass ratio with the use of Eindhoven nuclear microprobe. The ratios observed differed appreciably from that of hydroxyapatite (2.15), which is commonly referred to as the Ca component in arteries affected by atherosclerosis. Very small granular calcified structures were found in an early stage. Broadly, two types of calcified structures were observed: the Ca/P ratio corresponding to the advanced stage (3.18) was found higher compared to those for the early stage (1.46-1.77). It has been argued that besides phosphates, the large Ca/P ratio corresponding to intense calcification may be due to a Ca deposit with a different anion (oxalate, hydroxide or even carbonate), while, the lower ratios may be due to an additional inorganic phosphate. The distribution of S/P ratios was used to account for enhanced deposition of lipid materials in the affected area at the expense of proteins. © 2005 Elsevier B.V. All rights reserved.
Citation: Proceedings of Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, (2005), 257- 262
URI: https://doi.org/10.1016/j.nimb.2005.01.067
http://repository.iitr.ac.in/handle/123456789/15313
Issue Date: 2005
Keywords: Atherosclerosis
Calcification
Calcium
Nuclear microprobe
Phosphorus
PIXE
Spatial element distribution
ISSN: 0168583X
Author Scopus IDs: 47161194700
12752158900
7003294979
56984195100
7005529444
7102878246
Author Affiliations: Dutta, R.K., Cyclotron Laboratory, Department of Applied Physics, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, Netherlands
Roijers, R.B., Cyclotron Laboratory, Department of Applied Physics, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, Netherlands
Mutsaers, P.H.A., Cyclotron Laboratory, Department of Applied Physics, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, Netherlands
Pauwels, P., Department of Pathology, Academic Hospital Maastricht, Maastricht, Netherlands
De Goeij, J.J.M., Cyclotron Laboratory, Department of Applied Physics, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, Netherlands, Interfaculty Reactor Institute, Delft University of Technology, Mekelweg 15, 2629 JB Delft, Netherlands
Van Der Vusse, G.J., Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, P.O. Box 616, 6200 MD Maastricht, Netherlands
Funding Details: This research is supported by FOM (project number 00PMT13), The Netherlands.
Corresponding Author: Mutsaers, P.H.A.; Cyclotron Laboratory, Department of Applied Physics, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, Netherlands; email: p.h.a.mutsaers@tue.nl
Appears in Collections:Conference Publications [CY]

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