http://repository.iitr.ac.in/handle/123456789/1531| Title: | Efficient synthesis of heterocyclic compounds derived from 2,6-dioxopiperazine derivatives and their evaluation for anti-inflammatory and anticancer activities |
| Authors: | Kumar S. Kumar N. Roy, Partha Sondhi S.M. |
| Published in: | Medicinal Chemistry Research |
| Abstract: | Piperazine dione derivatives (1a-j) on condensation with 2,6-pyridine dicarboxylic acid (2x), 3,5-pyridine dicarboxylic acid (2y) and 2,5-thiophene dicarboxylic acid (2z) gave corresponding heterocyclic compounds 3ax-3jz in excellent yields. All the newly synthesized compounds were fully characterized by spectroscopic means and elemental analysis. On screening for anti-inflammatory and for in vitro anticancer activity, compounds 3bx, 3cx, 3dx, and 3ex exhibited good anti-inflammatory activity, whereas compounds 3ay, 3az, 3cz, 3dx, 3ez, 3fx, 3gx, and 3hz exhibited good anticancer activity. © Springer Science+Business Media 2014. |
| Citation: | Medicinal Chemistry Research (2014), 23(9): 3953-3969 |
| URI: | https://doi.org/10.1007/s00044-014-0969-1 http://repository.iitr.ac.in/handle/123456789/1531 |
| Issue Date: | 2014 |
| Publisher: | Birkhauser Boston |
| Keywords: | 2,6-Dioxopiperazine derivatives Anti-inflammatory Anticancer Synthesis |
| ISSN: | 10542523 |
| Author Scopus IDs: | 57216459762 57201756182 35509207200 7006090710 |
| Author Affiliations: | Kumar, S., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, 247667, India Kumar, N., Department of Biotechnology, Indian Institute of Technology-Roorkee, Roorkee, 247667, India Roy, P., Department of Biotechnology, Indian Institute of Technology-Roorkee, Roorkee, 247667, India Sondhi, S.M., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, 247667, India |
| Funding Details: | Acknowledgments We are thankful to technical staff of the Chemistry Department, I. I. T. Roorkee, for spectroscopic studies and elemental analysis. Thanks also due to Head I.I.C. for providing NMR facility. Mr. Sandeep Kumar is thankful to MHRD New Delhi for financial assistance. |
| Corresponding Author: | Sondhi, S.M.; Department of Chemistry, Indian Institute of Technology-RoorkeeIndia |
| Appears in Collections: | Journal Publications [BT] |
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