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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/1531
Title: Efficient synthesis of heterocyclic compounds derived from 2,6-dioxopiperazine derivatives and their evaluation for anti-inflammatory and anticancer activities
Authors: Kumar S.
Kumar N.
Roy, Partha
Sondhi S.M.
Published in: Medicinal Chemistry Research
Abstract: Piperazine dione derivatives (1a-j) on condensation with 2,6-pyridine dicarboxylic acid (2x), 3,5-pyridine dicarboxylic acid (2y) and 2,5-thiophene dicarboxylic acid (2z) gave corresponding heterocyclic compounds 3ax-3jz in excellent yields. All the newly synthesized compounds were fully characterized by spectroscopic means and elemental analysis. On screening for anti-inflammatory and for in vitro anticancer activity, compounds 3bx, 3cx, 3dx, and 3ex exhibited good anti-inflammatory activity, whereas compounds 3ay, 3az, 3cz, 3dx, 3ez, 3fx, 3gx, and 3hz exhibited good anticancer activity. © Springer Science+Business Media 2014.
Citation: Medicinal Chemistry Research (2014), 23(9): 3953-3969
URI: https://doi.org/10.1007/s00044-014-0969-1
http://repository.iitr.ac.in/handle/123456789/1531
Issue Date: 2014
Publisher: Birkhauser Boston
Keywords: 2,6-Dioxopiperazine derivatives
Anti-inflammatory
Anticancer
Synthesis
ISSN: 10542523
Author Scopus IDs: 57216459762
57201756182
35509207200
7006090710
Author Affiliations: Kumar, S., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, 247667, India
Kumar, N., Department of Biotechnology, Indian Institute of Technology-Roorkee, Roorkee, 247667, India
Roy, P., Department of Biotechnology, Indian Institute of Technology-Roorkee, Roorkee, 247667, India
Sondhi, S.M., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, 247667, India
Funding Details: Acknowledgments We are thankful to technical staff of the Chemistry Department, I. I. T. Roorkee, for spectroscopic studies and elemental analysis. Thanks also due to Head I.I.C. for providing NMR facility. Mr. Sandeep Kumar is thankful to MHRD New Delhi for financial assistance.
Corresponding Author: Sondhi, S.M.; Department of Chemistry, Indian Institute of Technology-RoorkeeIndia
Appears in Collections:Journal Publications [BT]

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