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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/1521
Title: Structural and functional evolution of chitinase-like proteins from plants
Authors: Kesari P.
Patil D.N.
Kumar, P.
Tomar, Shailly
Sharma, Ashwani Kumar
Kumar, Pravindra R.Manish
Published in: Proteomics
Abstract: The plant genome contains a large number of sequences that encode catalytically inactive chitinases referred to as chitinase-like proteins (CLPs). Although CLPs share high sequence and structural homology with chitinases of glycosyl hydrolase 18 (TIM barrel domain) and 19 families, they may lack the binding/catalytic activity. Molecular genetic analysis revealed that gene duplication events followed by mutation in the existing chitinase gene have resulted in the loss of activity. The evidences show that adaptive functional diversification of the CLPs has been achieved through alterations in the flexible regions than in the rigid structural elements. The CLPs plays an important role in the defense response against pathogenic attack, biotic and abiotic stress. They are also involved in the growth and developmental processes of plants. Since the physiological roles of CLPs are similar to chitinase, such mutations have led to plurifunctional enzymes. The biochemical and structural characterization of the CLPs is essential for understanding their roles and to develop potential utility in biotechnological industries. This review sheds light on the structure-function evolution of CLPs from chitinases. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Citation: Proteomics(2015), 15(10): 1693-1705
URI: https://doi.org/10.1002/pmic.201400421
http://repository.iitr.ac.in/handle/123456789/1521
Issue Date: 2015
Publisher: Wiley-VCH Verlag
Keywords: Chitinase-like proteins
Glycosyl hydrolase family
N-Acetylglucosamine
Plant proteomics
TIM barrel
ISSN: 16159853
Author Scopus IDs: 57218355625
26431600400
57204102455
57203506001
57214355701
55064809000
Author Affiliations: Kesari, P., Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, India
Patil, D.N., Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, India
Kumar, P., Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, India
Tomar, S., Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, India
Sharma, A.K., Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, India
Kumar, P., Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, India
Corresponding Author: Kumar, P.; Department of Biotechnology, Indian Institute of Technology RoorkeeIndia
Appears in Collections:Journal Publications [BT]

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