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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/1512
Title: Biocompatibility of ultrafine grained zircaloy-2 produced by cryorolling for medical applications
Authors: Trivedi P.
Goel S.
Das S.
Jayaganthan R.
Lahiri, Debrupa
Roy, Partha
Published in: Materials Science and Engineering C
Abstract: The present work deals with development of ultrafine grained zircaloy-2 and studying its potential for orthopedic application. The multimodal structure, i.e. the combination of coarse, ultrafine grained (UFG) and nanograined structures of zircaloy-2 is obtained by cryorolling the bulk alloy followed by annealing at 400 °C, and 450 °C for 30 min. An estimation of surface wettability of the alloy was obtained through contact angle measurement. The bioactivity of the alloy samples was investigated by incubating bone marrow derived stem cells. The cellular attachment, adhesion and proliferation at different intervals of incubation were characterized by scanning fluorescent microscopy and MTT assay. Cell culture results indicated that liquid nitrogen rolled alloy samples exhibited excellent in-vitro biocompatibility together with satisfactory bioactivity. Excellent genomic expressions were observed for zircaloy 2 processed by cryorolling. © 2014 Elsevier B.V. All rights reserved.
Citation: Materials Science and Engineering C (2015), 46(): 309-315
URI: https://doi.org/10.1016/j.msec.2014.10.056
http://repository.iitr.ac.in/handle/123456789/1512
Issue Date: 2015
Publisher: Elsevier Ltd
Keywords: Bioactivity
Cryorolling
Microstructure
Wettability
ISSN: 9284931
Author Scopus IDs: 55999013600
57206032668
57198673922
6602183770
26326345700
35509207200
Author Affiliations: Trivedi, P., Centre of Nanotechnology, Indian Institute of Technology Roorkee, Roorkee, 247667, India
Goel, S., Department of Metallurgical and Materials Engineering, Indian Institute of Technology, Roorkee, India
Das, S., Department of Biotechnology, Indian Institute of Technology, Roorkee, India
Jayaganthan, R., Centre of Nanotechnology, Indian Institute of Technology Roorkee, Roorkee, 247667, India, Department of Metallurgical and Materials Engineering, Indian Institute of Technology, Roorkee, India
Lahiri, D., Centre of Nanotechnology, Indian Institute of Technology Roorkee, Roorkee, 247667, India, Department of Metallurgical and Materials Engineering, Indian Institute of Technology, Roorkee, India
Roy, P., Department of Biotechnology, Indian Institute of Technology, Roorkee, India
Corresponding Author: Jayaganthan, R.; Centre of Nanotechnology, Indian Institute of Technology RoorkeeIndia
Appears in Collections:Journal Publications [BT]
Journal Publications [MT]

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