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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/1506
Title: Microwave-assisted synthesis of benzenesulfonohydrazide and benzenesulfonamide cyclic imide hybrid molecules and their evaluation for anticancer activity
Authors: Kumar A.
Kumar N.
Roy, Partha
Sondhi S.M.
Sharma A.
Published in: Medicinal Chemistry Research
Abstract: 4-Methyl benzenesulfonohydrazide (1a) and 4-methoxy benzenesulfonohydrazide (1b) on condensation with furan-2,5-dione, hexahydroisobenzofuran-1,3-dione, 3a,4,7,7a-tetrahydroisobenzofuran-1,3-dione and isochroman-1,3-dione under microwave irradiation condition gave corresponding condensation products 2a,b; 3a,b; 4a,b and 5a,b, respectively, in good yields. Microwave-assisted condensation of 4-amino-N-(thiazol-2-yl)benzenesulfonamide (6a), 4-amino-N-(pyrimidin-2-yl)benzenesulfonamide (6b) and 4-amino-N-(4-methyl pyrimidin-2-yl)benzenesulfonamide (6c) with furan-2,5-dione, hexahydroisobenzofuran-1,3-dione, 3a,4,7,7a-tetrahydroisobenzofuran-1,3-dione and isochroman-1,3-dione gave corresponding condensation products 7a-c, 8a-c, 9a-c and 10a-c, respectively, in good yields. All these compounds, i.e., 2a,b; 3a,b; 4a,b; 5a,b; 7a-c; 8a-c; 9a-c and 10a-c, were screened for in vitro anticancer activity against five human cancer cell lines, i.e., breast (T47D), lung (NCl H-522), colon (HCT-15), ovary (PA-1) and liver (Hep G2). Compounds 7c and 9c exhibited good anticancer activity against ovary (PA-1) (IC<inf>50</inf> value 8.12 ± 1.83 ?M) and liver (Hep G2) (IC<inf>50</inf> value 4 ± 1.9 ?M) cancer cell lines, respectively. © 2015 Springer Science+Business Media New York.
Citation: Medicinal Chemistry Research (2015), 24(10): 3760-3771
URI: https://doi.org/10.1007/s00044-015-1414-9
http://repository.iitr.ac.in/handle/123456789/1506
Issue Date: 2015
Publisher: Birkhauser Boston
Keywords: Anticancer activity
Benzenesulfonamide
Benzenesulfonohydrazide
Microwave
ISSN: 10542523
Author Scopus IDs: 57209569608
57201756182
35509207200
7006090710
57210795172
Author Affiliations: Kumar, A., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, Uttrakhand, 247667, India
Kumar, N., Department of Biotechnology, Indian Institute of Technology-Roorkee, Roorkee, Uttrakhand, 247667, India
Roy, P., Department of Biotechnology, Indian Institute of Technology-Roorkee, Roorkee, Uttrakhand, 247667, India
Sondhi, S.M., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, Uttrakhand, 247667, India
Sharma, A., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, Uttrakhand, 247667, India
Corresponding Author: Sharma, A.; Department of Chemistry, Indian Institute of Technology-RoorkeeIndia
Appears in Collections:Journal Publications [BT]

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