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dc.contributor.authorArya S.-
dc.contributor.authorKumar A.-
dc.contributor.authorKumar N.-
dc.contributor.authorRoy, Partha-
dc.contributor.authorSondhi S.M.-
dc.date.accessioned2020-09-30T11:39:12Z-
dc.date.available2020-09-30T11:39:12Z-
dc.date.issued2015-
dc.identifier.citationMedicinal Chemistry Research (2015), 24(5): 1942-1951-
dc.identifier.issn10542523-
dc.identifier.urihttps://doi.org/10.1007/s00044-014-1268-6-
dc.identifier.urihttp://repository.iitr.ac.in/handle/123456789/1500-
dc.description.abstractAbstract 9-Amino acridine derivatives (1a-1h) on condensation with 9, 10-dihydroanthracene-9, 10-?, ?-succinic anhydride (2) at room temperature gave condensation products (3a-3h). Microwave-assisted condensation of 9-amino acridine derivatives (1a-1d) with phthalic anhydride, cis 1,2,3,6-tetrahydrophthalimide, and 2,5-pyrroledione gave corresponding condensation products 4a-4d, 5a-5d & 6a-6d, respectively, in good yields. All these compounds were screened for in vitro anticancer activity against five human cancer cell lines i.e., breast (T47D), lung (NCl H-522), colon (HCT-15), ovary (PA-1), and liver (Hep G2). Compounds 3a (breast T47D), 3 g (lung NCl H-522), 4a (liver Hep G2), and 6b (colon HCT-15) exhibited IC50 values 5.4, 4.2, 4.5, and 2.4 ?M, respectively, and hence possess good anticancer activity. © 2014 Springer Science+Business Media New York.-
dc.language.isoen_US-
dc.publisherBirkhauser Boston-
dc.relation.ispartofMedicinal Chemistry Research-
dc.subjectAcridine derivatives-
dc.subjectAnticancer-
dc.subjectHuman cancer cell lines-
dc.subjectSynthesis-
dc.titleSynthesis and anticancer activity evaluation of some acridine derivatives-
dc.typeArticle-
dc.scopusid54402273600-
dc.scopusid57209569608-
dc.scopusid57201756182-
dc.scopusid35509207200-
dc.scopusid7006090710-
dc.affiliationArya, S., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, UK 247667, India-
dc.affiliationKumar, A., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, UK 247667, India-
dc.affiliationKumar, N., Department of Biotechnology, Indian Institute of Technology-Roorkee, Roorkee, UK 247667, India-
dc.affiliationRoy, P., Department of Biotechnology, Indian Institute of Technology-Roorkee, Roorkee, UK 247667, India-
dc.affiliationSondhi, S.M., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, UK 247667, India-
Appears in Collections:Journal Publications [BT]

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