Synthesis and anticancer activity evaluation of some acridine derivatives

Abstract

Abstract 9-Amino acridine derivatives (1a-1h) on condensation with 9, 10-dihydroanthracene-9, 10-?, ?-succinic anhydride (2) at room temperature gave condensation products (3a-3h). Microwave-assisted condensation of 9-amino acridine derivatives (1a-1d) with phthalic anhydride, cis 1,2,3,6-tetrahydrophthalimide, and 2,5-pyrroledione gave corresponding condensation products 4a-4d, 5a-5d & 6a-6d, respectively, in good yields. All these compounds were screened for in vitro anticancer activity against five human cancer cell lines i.e., breast (T47D), lung (NCl H-522), colon (HCT-15), ovary (PA-1), and liver (Hep G2). Compounds 3a (breast T47D), 3 g (lung NCl H-522), 4a (liver Hep G2), and 6b (colon HCT-15) exhibited IC50 values 5.4, 4.2, 4.5, and 2.4 ?M, respectively, and hence possess good anticancer activity. © 2014 Springer Science+Business Media New York.