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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/1500
Title: Synthesis and anticancer activity evaluation of some acridine derivatives
Authors: Arya S.
Kumar A.
Kumar N.
Roy, Partha
Sondhi S.M.
Published in: Medicinal Chemistry Research
Abstract: Abstract 9-Amino acridine derivatives (1a-1h) on condensation with 9, 10-dihydroanthracene-9, 10-?, ?-succinic anhydride (2) at room temperature gave condensation products (3a-3h). Microwave-assisted condensation of 9-amino acridine derivatives (1a-1d) with phthalic anhydride, cis 1,2,3,6-tetrahydrophthalimide, and 2,5-pyrroledione gave corresponding condensation products 4a-4d, 5a-5d & 6a-6d, respectively, in good yields. All these compounds were screened for in vitro anticancer activity against five human cancer cell lines i.e., breast (T47D), lung (NCl H-522), colon (HCT-15), ovary (PA-1), and liver (Hep G2). Compounds 3a (breast T47D), 3 g (lung NCl H-522), 4a (liver Hep G2), and 6b (colon HCT-15) exhibited IC50 values 5.4, 4.2, 4.5, and 2.4 ?M, respectively, and hence possess good anticancer activity. © 2014 Springer Science+Business Media New York.
Citation: Medicinal Chemistry Research (2015), 24(5): 1942-1951
URI: https://doi.org/10.1007/s00044-014-1268-6
http://repository.iitr.ac.in/handle/123456789/1500
Issue Date: 2015
Publisher: Birkhauser Boston
Keywords: Acridine derivatives
Anticancer
Human cancer cell lines
Synthesis
ISSN: 10542523
Author Scopus IDs: 54402273600
57209569608
57201756182
35509207200
7006090710
Author Affiliations: Arya, S., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, UK 247667, India
Kumar, A., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, UK 247667, India
Kumar, N., Department of Biotechnology, Indian Institute of Technology-Roorkee, Roorkee, UK 247667, India
Roy, P., Department of Biotechnology, Indian Institute of Technology-Roorkee, Roorkee, UK 247667, India
Sondhi, S.M., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, UK 247667, India
Appears in Collections:Journal Publications [BT]

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