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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/1499
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dc.contributor.authorKumar A.-
dc.contributor.authorKumar N.-
dc.contributor.authorRoy, Partha-
dc.contributor.authorSondhi S.M.-
dc.contributor.authorSharma A.-
dc.date.accessioned2020-09-30T11:39:12Z-
dc.date.available2020-09-30T11:39:12Z-
dc.date.issued2015-
dc.identifier.citationMedicinal Chemistry Research (2015), 24(8): 3272-3282-
dc.identifier.issn10542523-
dc.identifier.urihttps://doi.org/10.1007/s00044-015-1380-2-
dc.identifier.urihttp://repository.iitr.ac.in/handle/123456789/1499-
dc.description.abstract9-Amino acridine derivatives (1a-e) on condensation with dihydrofuran-2,5-dione, hexahydroisobenzofuran-1,3-dione and isochroman-1,3-dione under microwave irradiation gave corresponding condensation products 2a-e, 3a-e and 4a-e, respectively, in good yields. All these compounds were screened in vitro for anticancer activity against five human cancer cell lines, i.e., breast (T47D), lung (NCl H-522), colon (HCT-15), ovary (PA-1) and liver (Hep G2). Compounds 1-(3-methoxyacridine-9-yl) pyrrolidine-2,5-dione (2d) (ovary PA-1), 2-(2-methylacridine-9-yl)hexahydro-1H-isoindole-1,3(2H)-dione (3b) (lung NCl H-522), 2-(4-methylacridine-9-yl)hexahydro-1H-isoindole-1,3(2H)-dione (3c) (ovary PA-1), 2-(4-methoxyacridine-9-yl)hexahydro-1H-isoindole-1,3(2H)-dione (3e) (ovary PA-1) and 2-(2-methylacridine-9-yl)isoquinoline-1,3(2H,4H)-dione (4b) (ovary PA-1) exhibited IC<inf>50</inf> values 7.1, 8.0, 5.4, 10.0 and 6.56 ?M, respectively, and hence possess good anticancer activity. © 2015 Springer Science+Business Media New York.-
dc.language.isoen_US-
dc.publisherBirkhauser Boston-
dc.relation.ispartofMedicinal Chemistry Research-
dc.subjectAcridine cyclic imide-
dc.subjectAnticancer-
dc.subjectHuman cancer cell lines-
dc.subjectMicrowave-assisted synthesis-
dc.titleSynthesis of acridine cyclic imide hybrid molecules and their evaluation for anticancer activity-
dc.typeArticle-
dc.scopusid57209569608-
dc.scopusid57201756182-
dc.scopusid35509207200-
dc.scopusid7006090710-
dc.scopusid57210795172-
dc.affiliationKumar, A., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, Uttrakhand, 247667, India-
dc.affiliationKumar, N., Department of Biotechnology, Indian Institute of Technology-Roorkee, Roorkee, Uttrakhand, 247667, India-
dc.affiliationRoy, P., Department of Biotechnology, Indian Institute of Technology-Roorkee, Roorkee, Uttrakhand, 247667, India-
dc.affiliationSondhi, S.M., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, Uttrakhand, 247667, India-
dc.affiliationSharma, A., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, Uttrakhand, 247667, India-
dc.description.correspondingauthorSharma, A.; Department of Chemistry, Indian Institute of Technology-RoorkeeIndia-
Appears in Collections:Journal Publications [BT]

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