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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/1499
Title: Synthesis of acridine cyclic imide hybrid molecules and their evaluation for anticancer activity
Authors: Kumar A.
Kumar N.
Roy, Partha
Sondhi S.M.
Sharma A.
Published in: Medicinal Chemistry Research
Abstract: 9-Amino acridine derivatives (1a-e) on condensation with dihydrofuran-2,5-dione, hexahydroisobenzofuran-1,3-dione and isochroman-1,3-dione under microwave irradiation gave corresponding condensation products 2a-e, 3a-e and 4a-e, respectively, in good yields. All these compounds were screened in vitro for anticancer activity against five human cancer cell lines, i.e., breast (T47D), lung (NCl H-522), colon (HCT-15), ovary (PA-1) and liver (Hep G2). Compounds 1-(3-methoxyacridine-9-yl) pyrrolidine-2,5-dione (2d) (ovary PA-1), 2-(2-methylacridine-9-yl)hexahydro-1H-isoindole-1,3(2H)-dione (3b) (lung NCl H-522), 2-(4-methylacridine-9-yl)hexahydro-1H-isoindole-1,3(2H)-dione (3c) (ovary PA-1), 2-(4-methoxyacridine-9-yl)hexahydro-1H-isoindole-1,3(2H)-dione (3e) (ovary PA-1) and 2-(2-methylacridine-9-yl)isoquinoline-1,3(2H,4H)-dione (4b) (ovary PA-1) exhibited IC<inf>50</inf> values 7.1, 8.0, 5.4, 10.0 and 6.56 ?M, respectively, and hence possess good anticancer activity. © 2015 Springer Science+Business Media New York.
Citation: Medicinal Chemistry Research (2015), 24(8): 3272-3282
URI: https://doi.org/10.1007/s00044-015-1380-2
http://repository.iitr.ac.in/handle/123456789/1499
Issue Date: 2015
Publisher: Birkhauser Boston
Keywords: Acridine cyclic imide
Anticancer
Human cancer cell lines
Microwave-assisted synthesis
ISSN: 10542523
Author Scopus IDs: 57209569608
57201756182
35509207200
7006090710
57210795172
Author Affiliations: Kumar, A., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, Uttrakhand, 247667, India
Kumar, N., Department of Biotechnology, Indian Institute of Technology-Roorkee, Roorkee, Uttrakhand, 247667, India
Roy, P., Department of Biotechnology, Indian Institute of Technology-Roorkee, Roorkee, Uttrakhand, 247667, India
Sondhi, S.M., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, Uttrakhand, 247667, India
Sharma, A., Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, Uttrakhand, 247667, India
Corresponding Author: Sharma, A.; Department of Chemistry, Indian Institute of Technology-RoorkeeIndia
Appears in Collections:Journal Publications [BT]

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