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Title: Drug functionalized microbial polysaccharide based nanofibers as transdermal substitute
Authors: Vashisth P.
Srivastava A.K.
Nagar H.
Raghuwanshi N.
Sharan S.
Nikhil K.
Pruthi P.A.
Singh, Rajesh Pratap
Roy, Partha
Pruthi V.
Published in: Nanomedicine: Nanotechnology, Biology, and Medicine
Abstract: In order to promote the natural healing process, drug-functionalized nanofibrous transdermal substitute was fabricated using gellan as chief polymer and polyvinyl alcohol (PVA) as supporting polymer via electrospinning technique. These fabricated nanofibers physiochemically mimic the extracellular matrix (ECM) which supports the cell growth. For neo-tissue regeneration in a sterilized environment, amoxicillin (Amx) was entrapped within these nanofibers. Entrapment of Amx in the nanofibers was confirmed by FESEM, FTIR, XRD and TG analysis. In vitro cell culture studies revealed that the fabricated non-cytotoxic nanofibers promoted enhance cell adherence and proliferation of human keratinocytes. A preliminary in vivo study performed on rat model for full thickness skin excision wound demonstrated the prompt re-epithelialization in early phase and quicker collagen deposition in later phases of wound healing in case of Amx-functionalized gellan/PVA nanofibers. Data collectively confirmed the potential usage of gellan based electrospun nanofibers as transdermal substitute for faster skin restoration. © 2015 Elsevier Inc.
Citation: Nanomedicine: Nanotechnology, Biology, and Medicine(2016), 12(5): 1375-1385
Issue Date: 2016
Publisher: Elsevier Inc.
Keywords: Electrospinning
Transdermal substitute
Wound healing
ISSN: 15499634
Author Scopus IDs: 55930984400
Author Affiliations: Vashisth, P., Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, India
Srivastava, A.K., Sapience Bio-Analytical Research Lab Bhopal, Madhya Pradesh, India
Nagar, H., Sapience Bio-Analytical Research Lab Bhopal,
Funding Details: Authors are also thankful to Dr. Narayan C. Mishra, and Institute Instrumentation Center, Indian Institute of Technology, Roorkee for providing research facilities for this work.
Corresponding Author: Pruthi, V.; Department of Biotechnology, Indian Institute of Technology RoorkeeIndia; email:
Appears in Collections:Journal Publications [BT]

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