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Title: A novel gellan-PVA nanofibrous scaffold for skin tissue regeneration: Fabrication and characterization
Authors: Vashisth P.
Nikhil K.
Roy, Partha
Pruthi P.A.
Singh, Rajesh Pratap
Pruthi V.
Published in: Carbohydrate Polymers
Abstract: In this investigation, we have introduced novel electrospun gellan based nanofibers as a hydrophilic scaffolding material for skin tissue regeneration. These nanofibers were fabricated using a blend mixture of gellan with polyvinyl alcohol (PVA). PVA reduced the repulsive force of resulting solution and lead to formation of uniform fibers with improved nanostructure. Field emission scanning electron microscopy (FESEM) confirmed the average diameter of nanofibers down to 50 nm. The infrared spectra (IR), differential scanning calorimetry (DSC) and X-ray diffraction (XRD) analysis evaluated the crosslinking, thermal stability and highly crystalline nature of gellan-PVA nanofibers, respectively. Furthermore, the cell culture studies using human dermal fibroblast (3T3L1) cells established that these gellan based nanofibrous scaffold could induce improved cell adhesion and enhanced cell growth than conventionally proposed gellan based hydrogels and dry films. Importantly, the nanofibrous scaffold are biodegradable and could be potentially used as a temporary substrate/or biomedical graft to induce skin tissue regeneration. © 2015 Elsevier Ltd. All rights reserved.
Citation: Carbohydrate Polymers(2016), 136(): 851-859
Issue Date: 2016
Publisher: Elsevier Ltd
Keywords: Electrospinning
Skin tissue regeneration
ISSN: 1448617
Author Scopus IDs: 55930984400
Author Affiliations: Vashisth, P., Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand 247667, India
Nikhil, K., Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand 247667, India
Roy, P., Depart
Funding Details: This work is supported by Council of Scientific and Industrial Research (CSIR, Grant no. 9895-35-44 ), Government of India. Authors are thankful to Dr. Narayan C. Mishra (Associate Professor), Department of polymer & process engineering and Institute Inst
Corresponding Author: Vashisth, P.; Department of Biotechnology, Indian Institute of Technology RoorkeeIndia
Appears in Collections:Journal Publications [BT]

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