Skip navigation
Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/14778
Title: Microgel/silica hybrid colloids: Bioinspired synthesis and controlled release application
Authors: Agrawal G.
Samal S.K.
Sethi S.K.
Manik, Gaurav
Agrawal R.
Published in: Polymer
Abstract: In the present work, we demonstrate that polymer based functional microgels can be used as autocatalytic template for the bioinspired deposition of silica nanoparticles inside the microgel network under ambient conditions. Temperature responsive poly(N-vinyl caprolactam) based microgels were synthesized by precipitation polymerization using glycidyl methacrylate as a comonomer. These microgels were further reacted with aminoethanthiol to develop amine functional groups inside the microgels. A water soluble silica precursor (PEGPEOS) was developed by modification of hyperbranched polyethoxysiloxane with polyethylene glycol monomethyl ether. Microgel/silica hybrid colloids were prepared by simultaneous PEGPEOS conversion and silica deposition in the microgels. TEM studies showed that silica nanoparticles of approximately 10 nm in size were deposited inside the microgel network owing to the strong acidbase interaction between the acidic silica and basic amine groups. DLS results indicated that the incorporation of silica nanoparticles reduced the thermal sensitivity of microgels. Molecular dynamics simulations were performed to investigate the interaction between silica precursor and microgels based on radial distribution function and interaction energy. The developed hybrid microgels were further explored for controlled release of aspirin used as a model drug. The preliminary results indicated that the presence of silica rich domains in the microgel network remarkably retarded aspirin release. © 2019 Elsevier Ltd
Citation: Polymer (2019), 178(): -
URI: https://doi.org/10.1016/j.polymer.2019.121599
http://repository.iitr.ac.in/handle/123456789/14778
Issue Date: 2019
Publisher: Elsevier Ltd
Keywords: Bioinspired
Controlled release
Microgels
Polyethoxysiloxane
ISSN: 323861
Author Scopus IDs: 25633493900
35171271600
57198345541
56595314900
56346252600
Author Affiliations: Agrawal, G., Department of Polymer and Process Engineering, Indian Institute of Technology Roorkee, Saharanpur Campus, Paper Mill Road, Saharanpur, Uttar Pradesh 247001, India
Samal, S.K., Materials Research Centre, Indian Institute of Science, Bangalore, 560 012, India
Sethi, S.K., Department of Polymer and Process Engineering, Indian Institute of Technology Roorkee, Saharanpur Campus, Paper Mill Road, Saharanpur, Uttar Pradesh 247001, India
Manik, G., Department of Polymer and Process Engineering, Indian Institute of Technology Roorkee, Saharanpur Campus, Paper Mill Road, Saharanpur, Uttar Pradesh 247001, India
Agrawal, R., Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1500, United States
Funding Details: Garima Agrawal thanks DST Inspire Faculty Award of the Department of Science and Technology, Government of India ( DST/INSPIRE/04/2015/003220 ) for the financial support. Sangram K. Samal highly acknowledges the Ramanujan fellowship ( SB/S2/RJN-038/2016 ) of Department of Science and Technology , and Ramalingaswami Re-entry fellowship (Ref: D.O. No. BT/HRD/35/02/2006 ) of Department of Biotechnology, Government of India . Rahul Agrawal thanks Intramural Research Program of the National Cancer Institute, USA for the financial support. Authors thank Dr. Berit Bruester for assisting with measurements. Prof. Y. S. Negi and Polymers & Hybrid Materials Research Laboratory at Saharanpur campus of IIT Roorkee, are highly acknowledged. Appendix A
Corresponding Author: Agrawal, G.; Department of Polymer and Process Engineering, Indian Institute of Technology Roorkee, Saharanpur Campus, Paper Mill Road, India; email: garimafpt@iitr.ac.in
Appears in Collections:Journal Publications [PE]

Files in This Item:
There are no files associated with this item.
Show full item record


Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.