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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/14765
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dc.contributor.authorSauraj-
dc.contributor.authorKumar V.-
dc.contributor.authorKumar B.-
dc.contributor.authorDeeba F.-
dc.contributor.authorBano S.-
dc.contributor.authorKulshreshtha A.-
dc.contributor.authorGopinath, Packirisamy-
dc.contributor.authorNegi, Yuvraj Singh-
dc.date.accessioned2020-10-15T12:43:58Z-
dc.date.available2020-10-15T12:43:58Z-
dc.date.issued2019-
dc.identifier.citationInternational Journal of Biological Macromolecules (2019), 128(): 204-213-
dc.identifier.issn1418130-
dc.identifier.other30684574-
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2019.01.101-
dc.identifier.urihttp://repository.iitr.ac.in/handle/123456789/14765-
dc.description.abstractIn this study, self-assembled nanoparticles based on amphiphilic xylan-stearic acid (Xyl-SA) conjugates have been developed for the efficient delivery of 5-fluorouracil (5-FU) in cancer therapy. The self-assembled behavior of Xyl-SA conjugates in aqueous medium was investigated using pyrene as fluorescent probe. To enhance the loading efficacy of 5-FU, the lipophilic 5-fluorouracil-stearic acid (5-FUSA) prodrug was synthesized and subsequently encapsulated into the hydrophobic core of Xyl-SA NPs. The obtained Xyl-SA/5-FUSA NPs had an appropriate size (~278 nm), high drug loading of 5-FUSA (~14.6 wt%) and high physiological stability. The interaction of the Xyl-SA/5-FUSA NPs with blood components was investigated by hemolysis study. The cell cytotoxic studies demonstrated that Xyl-SA/5-FUSA NPs induced higher cytotoxicity than free drugs against the Human colorectal cancer cells (HT-29, HCT-15). These results indicate that Xyl-SA/5-FUSA NPs can serve as a promising drug delivery system for the efficient delivery of 5-FU in cancer therapy. © 2019 Elsevier B.V.-
dc.language.isoen_US-
dc.publisherElsevier B.V.-
dc.relation.ispartofInternational Journal of Biological Macromolecules-
dc.subjectCell cytotoxicity-
dc.subjectSelf-assembled nanoparticles-
dc.subjectXylan-
dc.titleLipophilic 5-fluorouracil prodrug encapsulated xylan-stearic acid conjugates nanoparticles for colon cancer therapy-
dc.typeArticle-
dc.scopusid57192377506-
dc.scopusid57208634573-
dc.scopusid9942788100-
dc.scopusid56113434700-
dc.scopusid57192374387-
dc.scopusid57203820180-
dc.scopusid56242963200-
dc.scopusid6701821524-
dc.affiliationSauraj, Department of Polymer and Process Engineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakha nd-247667, India-
dc.affiliationKumar, V., Nano-biotechnology Laboratory, Centre for Nanotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakha nd-247667, India-
dc.affiliationKumar, B., Department of Polymer and Process Engineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakha nd-247667, India-
dc.affiliationDeeba, F., Department of Polymer and Process Engineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakha nd-247667, India-
dc.affiliationBano, S., Department of Polymer and Process Engineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakha nd-247667, India-
dc.affiliationKulshreshtha, A., Department of Paper Technology, Indian Institute of Technology Roorkee, Roorkee, Uttarakha nd-247667, India-
dc.affiliationGopinath, P., Nano-biotechnology Laboratory, Centre for Nanotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakha nd-247667, India-
dc.affiliationNegi, Y.S., Department of Polymer and Process Engineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakha nd-247667, India-
dc.description.fundingThe authors would like to thanks the MHRD New Delhi for a Ph.D. scholarship. The authors also thanks department of chemistry (IIT-Roorkee) for their convenience helps. Appendix A-
dc.description.correspondingauthorNegi, Y.S.; Department of Polymer and Process Engineering, Indian Institute of Technology RoorkeeIndia; email: ynegifpt@iitr.ernet.in-
Appears in Collections:Journal Publications [PE]

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