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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/14765
Title: Lipophilic 5-fluorouracil prodrug encapsulated xylan-stearic acid conjugates nanoparticles for colon cancer therapy
Authors: Sauraj
Kumar V.
Kumar B.
Deeba F.
Bano S.
Kulshreshtha A.
Gopinath, Packirisamy
Negi, Yuvraj Singh.
Published in: International Journal of Biological Macromolecules
Abstract: In this study, self-assembled nanoparticles based on amphiphilic xylan-stearic acid (Xyl-SA) conjugates have been developed for the efficient delivery of 5-fluorouracil (5-FU) in cancer therapy. The self-assembled behavior of Xyl-SA conjugates in aqueous medium was investigated using pyrene as fluorescent probe. To enhance the loading efficacy of 5-FU, the lipophilic 5-fluorouracil-stearic acid (5-FUSA) prodrug was synthesized and subsequently encapsulated into the hydrophobic core of Xyl-SA NPs. The obtained Xyl-SA/5-FUSA NPs had an appropriate size (~278 nm), high drug loading of 5-FUSA (~14.6 wt%) and high physiological stability. The interaction of the Xyl-SA/5-FUSA NPs with blood components was investigated by hemolysis study. The cell cytotoxic studies demonstrated that Xyl-SA/5-FUSA NPs induced higher cytotoxicity than free drugs against the Human colorectal cancer cells (HT-29, HCT-15). These results indicate that Xyl-SA/5-FUSA NPs can serve as a promising drug delivery system for the efficient delivery of 5-FU in cancer therapy. © 2019 Elsevier B.V.
Citation: International Journal of Biological Macromolecules (2019), 128(): 204-213
URI: https://doi.org/10.1016/j.ijbiomac.2019.01.101
http://repository.iitr.ac.in/handle/123456789/14765
Issue Date: 2019
Publisher: Elsevier B.V.
Keywords: Cell cytotoxicity
Self-assembled nanoparticles
Xylan
ISSN: 1418130
Author Scopus IDs: 57192377506
57208634573
9942788100
56113434700
57192374387
57203820180
56242963200
6701821524
Author Affiliations: Sauraj, Department of Polymer and Process Engineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakha nd-247667, India
Kumar, V., Nano-biotechnology Laboratory, Centre for Nanotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakha nd-247667, India
Kumar, B., Department of Polymer and Process Engineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakha nd-247667, India
Deeba, F., Department of Polymer and Process Engineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakha nd-247667, India
Bano, S., Department of Polymer and Process Engineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakha nd-247667, India
Kulshreshtha, A., Department of Paper Technology, Indian Institute of Technology Roorkee, Roorkee, Uttarakha nd-247667, India
Gopinath, P., Nano-biotechnology Laboratory, Centre for Nanotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakha nd-247667, India
Negi, Y.S., Department of Polymer and Process Engineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakha nd-247667, India
Funding Details: The authors would like to thanks the MHRD New Delhi for a Ph.D. scholarship. The authors also thanks department of chemistry (IIT-Roorkee) for their convenience helps. Appendix A
Corresponding Author: Negi, Y.S.; Department of Polymer and Process Engineering, Indian Institute of Technology RoorkeeIndia; email: ynegifpt@iitr.ernet.in
Appears in Collections:Journal Publications [PE]

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