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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/14658
Title: Cartilage tissue engineering: Current scenario and challenges
Authors: Sharma C.
Gautam S.
Dinda A.K.
Mishra, Narayan Chandra
Published in: Advanced Materials Letters
Abstract: Cartilage is an avascular connective tissue found in many locations in the body, such as, in the joints between the bones, rib cage, ear, nose and intervertebral discs. Cartilage plays a vital role in our body by working as a cushion between joints so that rubbing of bones against each other is prevented. It also holds some bones together, for instance, rib cartilage, and makes the area shock-proof. Cartilage is composed of single type of cells called chondrocytes. There are several diseases associated with cartilage, e.g.,osteoarthritis, traumatic rupture of cartilage. These defects are not easy to repair as cartilage possesses limited self repair capacity due to the lack of a sufficient supply ofhealthy chondrocytes to the defective sites. Tissue engineered cartilage can serve as a lifelong treatment to such problems. Reconstruction of the cartilage can be achieved by use of appropriate cell source, scaffold, and growth factors. Development of a 3D cartilaginous skeleton have challenged the researchers for decades as the pursuit for suitable cell source, biomaterials and growth factor combination is not yet over. Various composite biomaterials and multiple growth factor approach are applied nowadays to regenerate cartilage. Stem cell has emerged as a potent source of cells for cartilage regeneration. This review highlightens the advances in cartilage tissue engineering by throwing light on cellsources, scaffold materials as well as on growth factors used so far in cartilage tissue engineering. It also reflects a range of problems and future perspectives to overcome theexisting hurdles in cartilage regeneration. © 2011 VBRI press.
Citation: Advanced Materials Letters (2011), 2(2): 90-99
URI: https://doi.org/10.5185/amlett.2011.1211
http://repository.iitr.ac.in/handle/123456789/14658
Issue Date: 2011
Keywords: Biomaterials
Cartilage
Chondrocytes
Tissue engineering
ISSN: 9763961
Author Scopus IDs: 55418158400
57213372885
7005837526
36798999600
Author Affiliations: Sharma, C., Department of Paper Technology, Indian Institute of Technology Roorkee, Saharanpur Campus, Saharanpur 247001, U.P, India
Gautam, S., Department of Paper Technology, Indian Institute of Technology Roorkee, Saharanpur Campus, Saharanpur 247001, U.P, India
Dinda, A.K., Department of Pathology, All India Institute of Medical Sciences, New Delhi 110029, India
Mishra, N.C., Department of Paper Technology, Indian Institute of Technology Roorkee, Saharanpur Campus, Saharanpur 247001, U.P, India
Corresponding Author: Mishra, N.C.; Department of Paper Technology, Indian Institute of Technology Roorkee, Saharanpur Campus, Saharanpur 247001, U.P, India; email: mishrawise@gmail.com
Appears in Collections:Journal Publications [PE]

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