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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/14641
Title: Antibiofilm activity of quercetin-encapsulated cytocompatible nanofibers against Candida albicans
Authors: Vashisth P.
Nikhil K.
Pemmaraju S.C.
Pruthi P.A.
Mallick V.
Singh H.
Patel A.
Mishra, Narayan Chandra
Singh, Rajesh Pratap
Pruthi V.
Published in: Journal of Bioactive and Compatible Polymers
Abstract: In this study, nanofibers against pro dimorphic fungal sessile growth were developed. Quercetin was successfully encapsulated within poly(d,l-lactide-co- glycolide)-poly(ε-caprolactone) nanofibers using an electrospinning technique. Field emission scanning electron microscopy, fluorescent microscopy, and Fourier-transformed infrared spectrometer were used to confirm the formation as well as encapsulation of quercetin within the nanofibers. These fabricated nanofibers were further evaluated to determine the effectiveness of the antibiofilm activity against Candida albicans. The cytocompatibility of quercetin-encapsulated nanofibers was found to be similar to control and pure polymeric nanofibers based on 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide assay against human embryonic kidney (HEK-293) cell lines. These fabricated nanofibers potentially could be used as coatings on biomedical devices to inhibit microbial contaminations. © 2013 The Author(s).
Citation: Journal of Bioactive and Compatible Polymers (2013), 28(6): 652-665
URI: https://doi.org/10.1177/0883911513502279
http://repository.iitr.ac.in/handle/123456789/14641
Issue Date: 2013
Keywords: antibiofilm activity
antimicobial coating
candida albican
cytocompatibility
electrospinning
HEK-293 cells
nanofibers
poly(ε-caprolactone)
poly(d,l-lactide-co-glycolide)
Quercetin
ISSN: 8839115
Author Scopus IDs: 55930984400
55661712000
54684894200
25958285300
55931345600
55452702700
55930061600
36798999600
57208931324
18837702800
Author Affiliations: Vashisth, P., Department of Biotechnology, Indian Institute of Technology Roorkee (IITR), Roorkee 247667, Uttarakhand, India
Nikhil, K., Department of Biotechnology, Indian Institute of Technology Roorkee (IITR), Roorkee 247667, Uttarakhand, India
Pemmaraju, S.C., Department of Biotechnology, Indian Institute of Technology Roorkee (IITR), Roorkee 247667, Uttarakhand, India
Pruthi, P.A., Department of Biotechnology, Indian Institute of Technology Roorkee (IITR), Roorkee 247667, Uttarakhand, India
Mallick, V., Department of Biotechnology, Indian Institute of Technology Roorkee (IITR), Roorkee 247667, Uttarakhand, India
Singh, H., Department of Biotechnology, Indian Institute of Technology Roorkee (IITR), Roorkee 247667, Uttarakhand, India
Patel, A., Department of Biotechnology, Indian Institute of Technology Roorkee (IITR), Roorkee 247667, Uttarakhand, India
Mishra, N.C., Department of Polymer Science and Engineering, Indian Institute of Technology Roorkee (IITR), Saharanpur, Uttar Pradesh, India
Singh, R.P., Department of Biotechnology, Indian Institute of Technology Roorkee (IITR), Roorkee 247667, Uttarakhand, India
Pruthi, V., Department of Biotechnology, Indian Institute of Technology Roorkee (IITR), Roorkee 247667, Uttarakhand, India
Funding Details: This study was funded by the Council of Scientific and Industrial Research (CSIR) and Department of Biotechnology (DBT) Government of India.
Corresponding Author: Pruthi, V.; Department of Biotechnology, Indian Institute of Technology Roorkee (IITR), Roorkee 247667, Uttarakhand, India; email: vikasfbs@iitr.ernet.in
Appears in Collections:Journal Publications [BT]
Journal Publications [PE]

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