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Please use this identifier to cite or link to this item: http://repository.iitr.ac.in/handle/123456789/14620
Title: "Amphotericin B" loaded natural biodegradable nanofibers as a potential drug delivery system against leishmaniasis
Authors: Nanda H.S.
Mishra, Narayan Chandra
Published in: Current Nanoscience
Abstract: Drug loaded nanofibers were prepared as a novel drug delivery system for the delivery of a medical drug--Amphotericin B which is the most promising drug for leishmaniasis (Kala-Azar). The nanofibers were prepared from 10 wt. % gelatin in acetic acid and water mixed with 1 wt. % Amphotericin B, and the fiber-morphology was studied by the Field Emission Scanning Electron Microscopy (FE-SEM). The formation of bead-free fibers was observed with an average diameter of 100nm, at optimal process conditions. The chemical integrity of the drug in the electrospun nanofibers, was confirmed by Fourier Transformation Infra Red (FTIR) spectroscopic analysis. The release of the Amphotericin B from the nanofibers, was investigated by UV-Visible spectrophotometer in phosphate buffer of pH 7.4 at normal physiological body temperature of 37°C. A controlled pattern for the release of Amphotericin B from the gelatin nanofibers, was observed - suggesting electrospun Amphotericin B loaded biodegradable nanofibers to be highly promising for the treatment of leishmaniasis (Kala-Azar). © 2011 Bentham Science Publishers.
Citation: Current Nanoscience (2011), 7(6): 943-949
URI: https://doi.org/10.2174/157341311798220628
http://repository.iitr.ac.in/handle/123456789/14620
Issue Date: 2011
Keywords: Drug delivery
Electrospinning
Gelatin
Kala-Azar
Leishmaniasis
Nanofibers
ISSN: 15734137
Author Scopus IDs: 56080002700
36798999600
Author Affiliations: Nanda, H.S., Center of Nanotechnology, Indian Institute of Technology Roorkee, Roorkee - 247667, India
Mishra, N.C., Department of Paper Technology, Indian Institute of Technology Roorkee, Saharanpur Campus, Saharanpur - 247001, India
Corresponding Author: Mishra, N. C.; Department of Paper Technology, Indian Institute of Technology Roorkee, Saharanpur Campus, Saharanpur - 247001, India; email: mishrawise@googlemail.com
Appears in Collections:Journal Publications [PE]

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