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Title: A controlled release system for quercetin from biodegradable poly(lactide-co-glycolide)-polycaprolactone nanofibers and its in vitro antitumor activity
Authors: Vashisth P.
Singh, Rajesh Pratap
Pruthi V.
Published in: Journal of Bioactive and Compatible Polymers
Abstract: Quercetin is a potent natural antioxidant but has limited therapeutic applications due to its short half-life in body fluids. In order to improve the efficacy of quercetin and overcome its shortcomings, quercetin-encapsulated electrospun poly(lactic-co-glycolic acid)-poly(?-caprolactone) nanofibrous controlled release system was developed using electrospinning technique. Fourier transform infrared spectroscopy, thermogravimetric, and X-ray diffraction analysis suggested the incorporation, thermal stability, and existence of encapsulated quercetin in semicrystalline state in the nanofibers. The release profiles of quercetin from the poly(lactide-co-glycolide)-polycaprolactone nanofibers in phosphate-buffered saline showed controlled release of quercetin up to 120 h. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay showed an evident inhibition effect of quercetin-encapsulated nanofibers against human hepatocellular carcinoma (HepG2), and the inhibition rate of 29%, 72%, and 80.1% were recorded for 1%, 2%, and 4% quercetin-encapsulated nanofibers, respectively. The formulated drug delivery system could be potentially used as an implantable anticancer drug in clinical applications in the future. © SAGE Publications.
Citation: Journal of Bioactive and Compatible Polymers(2016), 31(3): 260-272
Issue Date: 2016
Publisher: SAGE Publications Ltd
Keywords: antitumor activity
ISSN: 8839115
Author Scopus IDs: 55930984400
Author Affiliations: Vashisth, P., Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand 247667, India
Singh, R.P., Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand 247667, India
Pruthi, V., De
Funding Details: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study is financially supported by Council of Scientific and Industrial Research (grant no. 20-12/2009(ii)EU-IV), Gove
Corresponding Author: Vashisth, P.; Department of Biotechnology, Indian Institute of Technology RoorkeeIndia; email:
Appears in Collections:Journal Publications [BT]

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